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PMID: 9066259 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Transcription factors vs nucleosomes: regulation of the PHO5 promoter in yeast.

Trends in biochemical sciences ·Vol. 22 ·No. 3 ·1997-03-00 ·Pages 93-7

Svaren J, Hörz W

Abstract

Activation of the Saccharomyces cerevisiae PHO5 gene is accompanied by the disruption of four positioned nucleosomes at the promoter. The chromatin transition requires a DNA-binding protein, Pho4, and its transactivation domain. The mechanism of nucleosome disruption and the contribution of the nucleosomes to PHO5 regulation are reviewed.

MeSH Terms

Chromatin/chemistry,metabolism,ultrastructure Chromosomal Proteins, Non-Histone/genetics,metabolism DNA-Binding Proteins/genetics,metabolism Gene Expression Regulation, Fungal Membrane Transport Proteins/genetics Nucleosomes/chemistry,genetics,metabolism Phosphate Transport Proteins Promoter Regions, Genetic Saccharomyces cerevisiae Proteins Transcription Factors/genetics,metabolism Transcription, Genetic

Chemicals

Chromatin Chromosomal Proteins, Non-Histone DNA-Binding Proteins Membrane Transport Proteins Nucleosomes Phosphate Transport Proteins Saccharomyces cerevisiae Proteins Transcription Factors phosphate permease SPT2 protein, S cerevisiae

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Svaren J

Department of Pathology, Washington University School of Medicine, St Louis, MO 63110-1093, USA.

Hörz W

Article Info

Journal

Trends in biochemical sciences

Abbr.

Trends Biochem Sci

ISSN

0968-0004

DOI

10.1016/s0968-0004(97)01001-3

Published

1997-03-00

Pages

93-7

Language

English

Region

England

NLM ID

7610674

Subset

External Links

PubMed source DOI: 10.1016/s0968-0004(97)01001-3 View journal details

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Transcription factors vs nucleosomes: regulation of the PHO5 promoter in yeast.

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