Abstract
This paper updates the author's earlier hypothesis that Attention Deficit Hyperactivity Disorder (ADHD) reflects underactivity in Gray's Behavioral Inhibition System. Five areas of research are reviewed: (1) studies using the stop-signal task, (2) studies of errors of commission, (3) a study of inhibition indexed by eye movements, (4) a neuroimaging study of the corpus callosum, and (5) a study on the prediction of response to methylphenidate. Data from the many different dependent variables in these studies are interpreted as supporting disinhibition as a core deficit in ADHD.
MeSH Terms
Attention Deficit Disorder with Hyperactivity/diagnosis,drug therapy,psychology
Brain Mapping
Central Nervous System Stimulants/adverse effects,therapeutic use
Child
Humans
Inhibition, Psychological
Methylphenidate/therapeutic use
Chemicals
Central Nervous System Stimulants
Methylphenidate
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Quay H C
University of Miami, Coral Gables, Florida 33124, USA.
References (18)
18 references, click to expand
-
Hyperactivity and delay aversion--I. The effect of delay on choice.
J Child Psychol Psychiatry. 1992 Feb;33(2):387-98
PMID: 1564081
-
Validity of the diagnostic category of attention deficit disorder without hyperactivity: a review of the literature.
J Learn Disabil. 1991 Feb;24(2):110-20
PMID: 2010673
-
Inhibition in ADHD, aggressive, and anxious children: a biologically based model of child psychopathology.
J Abnorm Child Psychol. 1996 Feb;24(1):19-36
PMID: 8833026
-
Deficient inhibitory control in attention deficit hyperactivity disorder.
J Abnorm Child Psychol. 1995 Aug;23(4):411-37
PMID: 7560554
-
Effects of reward and response costs on inhibition in ADHD children.
J Abnorm Psychol. 1995 Feb;104(1):232-40
PMID: 7897047
-
Effects of methylphenidate on inhibitory control in hyperactive children.
J Abnorm Child Psychol. 1989 Oct;17(5):473-91
PMID: 2681316
-
An open trial of guanfacine in the treatment of attention-deficit hyperactivity disorder.
J Am Acad Child Adolesc Psychiatry. 1995 Jan;34(1):50-4
PMID: 7860456
-
Towards a model of stress and human performance.
Acta Psychol (Amst). 1983 Apr;53(1):61-97
PMID: 6869047
-
Optimal stimulation: a model of disordered activity and performance in normal and deviant children.
Psychol Bull. 1983 Nov;94(3):446-71
PMID: 6657825
-
Response perseveration, inhibitory control, and central dopaminergic activity in childhood behavior disorders.
J Genet Psychol. 1993 Jun;154(2):177-88
PMID: 8366330
-
Attention deficit hyperactivity disorder and the frontal lobe syndrome.
Brain Cogn. 1992 Sep;20(1):104-24
PMID: 1389116
-
Quantitative morphology of the corpus callosum in attention deficit hyperactivity disorder.
Am J Psychiatry. 1994 May;151(5):665-9
PMID: 8166306
-
Response perseveration and delayed responding in childhood behavior disorders.
J Child Psychol Psychiatry. 1991 Mar;32(3):453-61
PMID: 2061365
-
Eye movement task related to frontal lobe functioning in children with attention deficit disorder.
J Am Acad Child Adolesc Psychiatry. 1994 Jul-Aug;33(6):869-74
PMID: 8083144
-
Methylphenidate and cognitive flexibility: dissociated dose effects in hyperactive children.
J Abnorm Child Psychol. 1995 Apr;23(2):235-66
PMID: 7642836
-
Response perseveration and delayed responding in undersocialized aggressive conduct disorder.
J Abnorm Psychol. 1988 Aug;97(3):371-3
PMID: 3192833
-
The go-no-go paradigm in attention deficit disorder.
Ann Neurol. 1988 Nov;24(5):610-4
PMID: 3202613
-
Effect of anxiety on cognition, behavior, and stimulant response in ADHD.
J Am Acad Child Adolesc Psychiatry. 1989 Nov;28(6):882-7
PMID: 2808258