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PMID: 909611 Published · ppublish English Journal Article

Influence of enkephalin on K+-evoked efflux of putative neurotransmitters in rat brain. Selective inhibition of acetylcholine and dopamine release.

Naunyn-Schmiedeberg's archives of pharmacology ·Vol. 299 ·No. 2 ·1977-09-00 ·Pages 163-5

Subramanian N, Mitznegg P, Sprügel W, Domschke W, Domschke S, Wünsch E, Demling L

Abstract

In rat brain slices preincubated with various radiolabelled putative neurotransmitters, methionine-enkephalin diminished the potassium-evoked release of dopamine and acetylcholine. The effect was antagonised by naloxone. The potassium-induced effux of three other neurotransmitters, histamine, 5-hydroxy-tryptamine and gamma-aminobutyric acid, were unaffected by methionine-enkephalin. A probable physiological function for the endogenous ligands in specifically affecting the catecholaminergic and cholinergic transmission is suggested.

MeSH Terms
Acetylcholine/metabolism Animals Brain/drug effects,metabolism Dopamine/metabolism Endorphins/pharmacology Enkephalins/pharmacology Histamine/metabolism In Vitro Techniques Male Potassium/antagonists & inhibitors Rats Rats, Inbred Strains Serotonin/metabolism gamma-Aminobutyric Acid/metabolism
Chemicals
Endorphins Enkephalins Serotonin gamma-Aminobutyric Acid Histamine Acetylcholine Potassium Dopamine
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Subramanian N
Mitznegg P
Sprügel W
Domschke W
Domschke S
Wünsch E
Demling L
References (14)
14 references, click to expand
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Article Info
Journal
Naunyn-Schmiedeberg's archives of pharmacology
Abbr.
Naunyn Schmiedebergs Arch Pharmacol
ISSN
0028-1298
DOI
10.1007/BF00498558
Published
1977-09-00
Pages
163-5
Language
English
Region
Germany
NLM ID
0326264
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00498558 View journal details
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