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PMID: 910131 Published · ppublish English Comparative Study Journal Article Research Support, U.S. Gov't, P.H.S.

Elastase release from human alveolar macrophages: comparison between smokers and nonsmokers.

Science (New York, N.Y.) ·Vol. 198 ·No. 4314 ·1977-10-21 ·Pages 313-4

Rodriguez RJ, White RR, Senior RM, Levine EA

Abstract

Alveolar macrophages from smokers, in contrast to those of non-smokers, release elastase into serum-free culture medium. Since enzymes that digest elastin produce pulmonary emphysema in experimental animals, release of elastase by alveolar macrophages from smokers suggests that these cells are important in the pathogenesis of emphysema of smokers.

MeSH Terms
Adult Female Glucuronidase/metabolism Humans L-Lactate Dehydrogenase/metabolism Macrophages/enzymology Male Pancreatic Elastase/metabolism Pulmonary Alveoli/cytology,enzymology Pulmonary Emphysema/etiology Smoking/complications,physiopathology
Chemicals
L-Lactate Dehydrogenase Glucuronidase Pancreatic Elastase
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Rodriguez R J
White R R
Senior R M
Levine E A
Article Info
Journal
Science (New York, N.Y.)
Abbr.
Science
ISSN
0036-8075
DOI
10.1126/science.910131
Published
1977-10-21
Pages
313-4
Language
English
Region
United States
NLM ID
0404511
Subset
IM
External Links
PubMed source DOI: 10.1126/science.910131 View journal details
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