Molecular mimicry between Helicobacter pylori and the host.

Trends in microbiology ·Vol. 5 ·No. 2 ·1997-02-00 ·Pages 70-3

Appelmelk BJ, Negrini R, Moran AP, Kuipers EJ

Abstract

Helicobacter pylori lipopolysaccharide (LPS) expresses Lewis x and Lewis y blood group antigens that are identical to those occurring in the human gastric mucosa. During infection, antibodies against LPS, which bind to host Lewis antigens, may be induced. These consequently recognize gastric glycoprotein targets and cause autoimmune inflammation.

MeSH Terms

Animals Antibodies, Monoclonal/biosynthesis Autoantibodies/biosynthesis Bacterial Proteins/genetics,immunology Gastric Mucosa/immunology Helicobacter Infections/etiology,immunology,pathology Helicobacter pylori/genetics,immunology,pathogenicity Humans Lewis Blood Group Antigens/immunology Lipopolysaccharides/immunology Mice Molecular Mimicry

Chemicals

Antibodies, Monoclonal Autoantibodies Bacterial Proteins Lewis Blood Group Antigens Lipopolysaccharides

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Appelmelk B J

Dept of Medical Microbiology, Vrije Universiteit, Amsterdam, The Netherlands. [email protected]

Negrini R

Moran A P

Kuipers E J

Article Info

Journal

Trends in microbiology

Abbr.

Trends Microbiol

ISSN

0966-842X

DOI

10.1016/S0966-842X(96)10084-6

[email protected]

Published

1997-02-00

Pages

70-3

Language

English

Region

England

NLM ID

9310916

Subset

External Links

PubMed source DOI: 10.1016/S0966-842X(96)10084-6 View journal details

Analysis Services

Molecular mimicry between Helicobacter pylori and the host.

Contact

WeChat Official Account