Chromatin remodeling and transcription.

Current opinion in genetics & development ·Vol. 7 ·No. 2 ·1997-04-00 ·Pages 182-91

Tsukiyama T, Wu C

Abstract

Recent advances highlight two important chromatin remodeling systems involved in the transcriptional process. One system includes several members of the evolutionarily conserved SWI2/SNF2 family found in distinct multiprotein complexes with ATP-dependent nucleosome destabilizing activity; the other is the enzymatic system that governs histone acetylation and deacetylation. Identification of the catalytic subunits of these opposing histone-modifying activities reveal conserved proteins defined genetically as transcriptional regulators.

MeSH Terms

Acetylation Acetyltransferases Adenosine Triphosphate Animals Cell Cycle Proteins/metabolism Chromatin DNA/chemistry DNA Helicases DNA-Binding Proteins/metabolism Fungal Proteins/metabolism Histone Acetyltransferases Histone Deacetylases/metabolism Histones Humans Nuclear Proteins/metabolism Nucleic Acid Conformation Nucleosomes Protein Kinases/metabolism Saccharomyces cerevisiae Proteins TATA-Binding Protein Associated Factors Tetrahymena Transcription Factor TFIID Transcription Factors/metabolism Transcription, Genetic p300-CBP Transcription Factors

Chemicals

CHD1 protein, S cerevisiae Cell Cycle Proteins Chromatin DNA-Binding Proteins Fungal Proteins Histones Nuclear Proteins Nucleosomes SMARCA1 protein, human SMARCA2 protein, human Saccharomyces cerevisiae Proteins TATA-Binding Protein Associated Factors Transcription Factor TFIID Transcription Factors Adenosine Triphosphate DNA Acetyltransferases Histone Acetyltransferases p300-CBP Transcription Factors p300-CBP-associated factor Protein Kinases TATA-binding protein associated factor 250 kDa Histone Deacetylases SMARCA4 protein, human DNA Helicases CHD1 protein, human

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Tsukiyama T

Laboratory of Molecular Cell Biology, National Cancer Institute, National Institutes of Health, Building 37, Room 5E-26, Bethesda, Maryland, 20892-4255, USA.

Wu C

Article Info

Journal

Current opinion in genetics & development

Abbr.

Curr Opin Genet Dev

ISSN

0959-437X

DOI

10.1016/s0959-437x(97)80127-x

Published

1997-04-00

Pages

182-91

Language

English

Region

England

NLM ID

9111375

Subset

External Links

PubMed source DOI: 10.1016/s0959-437x(97)80127-x View journal details

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