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PMID: 9119989 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

Cytotoxic T cells and viral hepatitis.

The Journal of clinical investigation ·Vol. 99 ·No. 7 ·1997-04-01 ·Pages 1472-7

Chisari FV

Abstract

暂无摘要

MeSH Terms
Hepatitis B/immunology Hepatitis C/immunology Humans T-Lymphocytes, Cytotoxic/immunology
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Chisari F V
Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA.
References (50)
50 references, click to expand
  1. Cytotoxic T lymphocyte response to hepatitis C virus-derived peptides containing the HLA A2.1 binding motif.
    J Clin Invest. 1995 Feb;95(2):521-30 PMID: 7860734
  2. The transactivator gene of human T-cell leukemia virus type I is more variable within and between healthy carriers than patients with tropical spastic paraparesis.
    J Virol. 1994 Oct;68(10):6778-81 PMID: 8084014
  3. Patients with chronic hepatitis C have circulating cytotoxic T cells which recognize hepatitis C virus-encoded peptides binding to HLA-A2.1 molecules.
    J Virol. 1995 Apr;69(4):2462-70 PMID: 7884894
  4. Persistent hepatitis C virus infection in a chimpanzee is associated with emergence of a cytotoxic T lymphocyte escape variant.
    Proc Natl Acad Sci U S A. 1995 Mar 28;92(7):2755-9 PMID: 7708719
  5. Hepatitis C virus (HCV) genotype, tissue HCV antigens, hepatocellular expression of HLA-A,B,C, and intercellular adhesion-1 molecules. Clues to pathogenesis of hepatocellular damage and response to interferon treatment in patients with chronic hepatitis C.
    J Clin Invest. 1995 May;95(5):2067-75 PMID: 7738174
  6. Activation of a heterogeneous hepatitis B (HB) core and e antigen-specific CD4+ T-cell population during seroconversion to anti-HBe and anti-HBs in hepatitis B virus infection.
    J Virol. 1995 Jun;69(6):3358-68 PMID: 7538172
  7. Hepatitis B virus immunopathogenesis.
    Annu Rev Immunol. 1995;13:29-60 PMID: 7612225
  8. Up-regulation of MHC class I by flavivirus-induced peptide translocation into the endoplasmic reticulum.
    Immunity. 1995 Aug;3(2):207-14 PMID: 7544229
  9. Hepatitis B virus (HBV) sequence variation of cytotoxic T lymphocyte epitopes is not common in patients with chronic HBV infection.
    J Clin Invest. 1995 Sep;96(3):1527-34 PMID: 7544809
  10. Involvement of the CD95 (APO-1/Fas) receptor and ligand in liver damage.
    J Exp Med. 1995 Nov 1;182(5):1223-30 PMID: 7595193
  11. Cytokine receptors encoded by poxviruses: a lesson in cytokine biology.
    Immunol Today. 1995 Oct;16(10):474-8 PMID: 7576050
  12. HLA class I-restricted cytotoxic T lymphocytes specific for hepatitis C virus. Identification of multiple epitopes and characterization of patterns of cytokine release.
    J Clin Invest. 1995 Nov;96(5):2311-21 PMID: 7593618
  13. HBx protein of hepatitis B virus interacts with the C-terminal portion of a novel human proteasome alpha-subunit.
    Virus Genes. 1995;10(1):99-102 PMID: 7483296
  14. Viral mutations, TCR antagonism and escape from the immune response.
    Curr Opin Immunol. 1995 Aug;7(4):524-31 PMID: 7495517
  15. Intracellular inactivation of the hepatitis B virus by cytotoxic T lymphocytes.
    Immunity. 1996 Jan;4(1):25-36 PMID: 8574849
  16. Cytotoxic T lymphocyte responsiveness after resolution of chronic hepatitis B virus infection.
    J Clin Invest. 1996 Apr 1;97(7):1655-65 PMID: 8601631
  17. Viral cross talk: intracellular inactivation of the hepatitis B virus during an unrelated viral infection of the liver.
    Proc Natl Acad Sci U S A. 1996 May 14;93(10):4589-94 PMID: 8643448
  18. The hepatitis B virus (HBV) precore protein inhibits HBV replication in transgenic mice.
    J Virol. 1996 Oct;70(10):7056-61 PMID: 8794350
  19. Quantitative analysis of the peripheral blood cytotoxic T lymphocyte response in patients with chronic hepatitis C virus infection.
    J Clin Invest. 1996 Sep 15;98(6):1432-40 PMID: 8823309
  20. The hepatitis B virus persists for decades after patients' recovery from acute viral hepatitis despite active maintenance of a cytotoxic T-lymphocyte response.
    Nat Med. 1996 Oct;2(10):1104-8 PMID: 8837608
  21. Progressive liver injury in chronic hepatitis C infection correlates with increased intrahepatic expression of Th1-associated cytokines.
    Hepatology. 1996 Oct;24(4):759-65 PMID: 8855173
  22. Posttranscriptional regulation of hepatitis B virus replication by the precore protein.
    J Virol. 1997 Jan;71(1):345-53 PMID: 8985356
  23. Acute type A hepatitis during chronic hepatitis B virus infection: association of depressed hepatitis B virus replication with appearance of endogenous alpha interferon.
    J Med Virol. 1984;14(2):141-7 PMID: 6491642
  24. Transmission of hepatitis B from hepatitis-B-seronegative subjects.
    Lancet. 1988 Dec 3;2(8623):1273-6 PMID: 2904005
  25. Hepatitis B core antigen-specific IFN-gamma production of peripheral blood mononuclear cells in patients with chronic hepatitis B virus infection.
    J Immunol. 1989 Jun 1;142(11):4006-11 PMID: 2469730
  26. Immunobiology and pathogenesis of hepatocellular injury in hepatitis B virus transgenic mice.
    Science. 1990 Apr 20;248(4953):361-4 PMID: 1691527
  27. Wild-type and e antigen-minus hepatitis B viruses and course of chronic hepatitis.
    Proc Natl Acad Sci U S A. 1991 May 15;88(10):4186-90 PMID: 2034663
  28. HLA class I-restricted human cytotoxic T cells recognize endogenously synthesized hepatitis B virus nucleocapsid antigen.
    Proc Natl Acad Sci U S A. 1991 Dec 1;88(23):10445-9 PMID: 1660137
  29. Intrahepatic cytotoxic T lymphocytes specific for hepatitis C virus in persons with chronic hepatitis.
    J Immunol. 1992 Nov 15;149(10):3339-44 PMID: 1385523
  30. Lack of protective immunity against reinfection with hepatitis C virus.
    Science. 1992 Oct 2;258(5079):135-40 PMID: 1279801
  31. HLA-A31- and HLA-Aw68-restricted cytotoxic T cell responses to a single hepatitis B virus nucleocapsid epitope during acute viral hepatitis.
    J Exp Med. 1993 Mar 1;177(3):751-62 PMID: 7679709
  32. HLA-A11 epitope loss isolates of Epstein-Barr virus from a highly A11+ population.
    Science. 1993 Apr 2;260(5104):98-100 PMID: 7682013
  33. HLA A2 restricted cytotoxic T lymphocyte responses to multiple hepatitis B surface antigen epitopes during hepatitis B virus infection.
    J Immunol. 1993 May 15;150(10):4659-71 PMID: 7683326
  34. Hepatitis C virus-specific CTL responses in the liver of chimpanzees with acute and chronic hepatitis C.
    J Immunol. 1993 Oct 15;151(8):4189-99 PMID: 7691940
  35. HLA B44-restricted cytotoxic T lymphocytes recognizing an epitope on hepatitis C virus nucleocapsid protein.
    Hepatology. 1993 Nov;18(5):1039-44 PMID: 7693568
  36. Mechanisms of class I restricted immunopathology. A transgenic mouse model of fulminant hepatitis.
    J Exp Med. 1993 Nov 1;178(5):1541-54 PMID: 8228807
  37. Hepatitis C virus (HCV)-specific cytotoxic T lymphocytes recognize epitopes in the core and envelope proteins of HCV.
    J Virol. 1993 Dec;67(12):7522-32 PMID: 7693974
  38. Interferon-gamma production specific for hepatitis B virus antigen by intrahepatic T lymphocytes in patients with acute and chronic hepatitis B.
    Am J Gastroenterol. 1994 Jan;89(1):92-6 PMID: 8273806
  39. "Occult" hepatitis B virus as source of infection in liver transplant recipients.
    Lancet. 1994 Jan 15;343(8890):142-6 PMID: 7904004
  40. Neutralizing antibodies against hepatitis C virus and the emergence of neutralization escape mutant viruses.
    J Virol. 1994 Mar;68(3):1494-500 PMID: 8107212
  41. Enhanced replication of a hepatitis B virus mutant associated with an epidemic of fulminant hepatitis.
    J Virol. 1994 Mar;68(3):1651-9 PMID: 8107226
  42. Selective expansion of cytotoxic T lymphocytes with a CD4+CD56+ surface phenotype and a T helper type 1 profile of cytokine secretion in the liver of patients chronically infected with Hepatitis B virus.
    J Immunol. 1994 Mar 15;152(6):3074-87 PMID: 7511637
  43. Class I-restricted cytotoxic T lymphocytes are directly cytopathic for their target cells in vivo.
    J Immunol. 1994 Apr 1;152(7):3245-53 PMID: 8144915
  44. Longitudinal analysis of T cell receptor (TCR) gene usage by human immunodeficiency virus 1 envelope-specific cytotoxic T lymphocyte clones reveals a limited TCR repertoire.
    J Exp Med. 1994 Apr 1;179(4):1261-71 PMID: 8145043
  45. Immunohistochemical detection of Fas antigen in liver tissue of patients with chronic hepatitis C.
    Hepatology. 1994 Jun;19(6):1354-9 PMID: 7514559
  46. Cytotoxic T-cell activity antagonized by naturally occurring HIV-1 Gag variants.
    Nature. 1994 Jun 2;369(6479):403-7 PMID: 7515165
  47. Natural variants of cytotoxic epitopes are T-cell receptor antagonists for antiviral cytotoxic T cells.
    Nature. 1994 Jun 2;369(6479):407-10 PMID: 8196768
  48. Prevention of hepatitis C virus infection in chimpanzees after antibody-mediated in vitro neutralization.
    Proc Natl Acad Sci U S A. 1994 Aug 2;91(16):7792-6 PMID: 7519785
  49. Cytotoxic T lymphocyte response to a wild type hepatitis B virus epitope in patients chronically infected by variant viruses carrying substitutions within the epitope.
    J Exp Med. 1994 Sep 1;180(3):933-43 PMID: 7520476
  50. The cytotoxic T lymphocyte response to multiple hepatitis B virus polymerase epitopes during and after acute viral hepatitis.
    J Exp Med. 1995 Mar 1;181(3):1047-58 PMID: 7532675
Article Info
Journal
The Journal of clinical investigation
Abbr.
J Clin Invest
ISSN
0021-9738
DOI
10.1172/JCI119308
Published
1997-04-01
Pages
1472-7
Language
English
Region
United States
NLM ID
7802877
PMCID
PMC507965
Subset
IM
Grants
NIAID NIH HHS · AI20001 · United States
NCI NIH HHS · CA40489 · United States
NCI NIH HHS · CA54560 · United States
External Links
PubMed source DOI: 10.1172/JCI119308 PMC Full Text View journal details
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