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PMID: 9122253 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Decreased probability of neurotransmitter release underlies striatal long-term depression and postnatal development of corticostriatal synapses.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 94 ·No. 6 ·1997-03-18 ·Pages 2665-70

Choi S, Lovinger DM

Abstract

Changes in synaptic efficacy are crucial for the development of appropriate neural circuits and brain information storage. We have investigated mechanisms underlying long-term depression (LTD) at glutamatergic synapses in the striatum, a brain region important in motor performance and cognition, and a target for Huntington and Parkinson diseases. Induction of striatal LTD is dependent on postsynaptic depolarization and calcium influx through L-type channels. Surprisingly, LTD maintenance appears to involve a decrease in the probability of neurotransmitter release from presynaptic terminals as evidenced by increases in paired-pulse facilitation and the coefficient of variation of synaptic responses that are tightly associated with LTD expression. Furthermore, both the apparent probability of neurotransmitter release and the magnitude of LTD decrease concomitantly during postnatal development, consistent with the idea that striatal LTD is involved in a developmental decrease in the probability of neurotransmitter release at corticostriatal synapses. The presynaptic changes that underlie striatal LTD may also be important for motor performance and certain forms of learning and memory.

MeSH Terms
Aging/physiology Animals Calcium/pharmacology Corpus Striatum/growth & development,physiology Electric Stimulation Evoked Potentials In Vitro Techniques Long-Term Potentiation Magnesium/pharmacology Neuronal Plasticity/drug effects Neurotransmitter Agents/physiology Patch-Clamp Techniques Rats Rats, Sprague-Dawley Synapses/physiology Time Factors
Chemicals
Neurotransmitter Agents Magnesium Calcium
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Choi S
Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232-0615, USA.
Lovinger D M
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.94.6.2665
Published
1997-03-18
Pages
2665-70
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC20146
Subset
IM
Grants
NINDS NIH HHS · NS30470 · United States
External Links
PubMed source DOI: 10.1073/pnas.94.6.2665 PMC Full Text View journal details
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