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PMID: 912324 Published · ppublish English Clinical Trial Controlled Clinical Trial Journal Article

Prospective trial of oestrogen and calcium in postmenopausal women.

British medical journal ·Vol. 2 ·No. 6090 ·1977-09-24 ·Pages 789-92

Horsman A, Gallagher JC, Simpson M, Nordin BE

Abstract

In a prospective trial in 72 postmenopausal women to compare the effects on bone loss of no treatment, treatment with oestrogen, and treatment with calcium the women were followed up for at least two years and examined densitometrically and morphometrically. Women in the untreated control group continued to lose bone during the two years, whereas the oestrogen-treated group lost none. Loss in the calcium-treated group was intermediate. Oestrogen appeared to inhibit endosteal bone resorption and may have stimulated subperiosteal bone apposition.

Keywords

Clinical Research Comparative Studies Contraception Contraceptive Agents Estrogen--administraction and dosage Contraceptive Agents Estrogen--therapeutic use Contraceptive Agents Female--administraction and dosage Contraceptive Agents Female--therapeutic use Contraceptive Agents--administraction and dosage Contraceptive Agents--therapeutic use Ethinyl Estradiol--administraction and dosage Ethinyl Estradiol--therapeutic use Family Planning Menopause Prospective Studies Reproduction Research Methodology Studies

MeSH Terms

Aged Bone Resorption/prevention & control Calcium/therapeutic use Densitometry Estrogens/therapeutic use Female Humans Menopause Middle Aged Prospective Studies

Chemicals

Estrogens Calcium

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Horsman A

Gallagher J C

Simpson M

Nordin B E

Other Abstracts

eng

72 of 89 postmenopausal women who started the prospective trial completed it

of these, 50 had had bilateral oophorectomy. The effects on bone loss were compared for no treatment, treatment with estrogen, or treatment with calcium. The estrogen-treated group received ethinyl estradiol 25 or 50 mcg for 3 of every 4 weeks. Calcium-treated patients took 2 calcium gluconate tablets/day, equal to 800 mg of calcium. Densitometry tests determined the mineral content of the left ulna and radius by the photon absorption technique. Morphometry was measured from radiographs of both hands. Untreated patients continued to lose bone density over the 2-year follow-up period. Those treated with estrogen did not lose bone density. Those treated with calcium had some bone loss but less than the untreated subjects. The main effect of estrogen on the metacarpals was inhibition of endosteal bone resorption with possibly stimulation of subperiosteal bone apposition.

References (3)

3 references, click to expand

Geometric properties of the second metacarpal.
Calcif Tissue Res. 1972;10(4):289-301 PMID: 4641754
The measurement of sequential changes in cortical bone geometry.
Br J Radiol. 1975 Jun;48(570):471-6 PMID: 1227702
Prevention of postmenopausal osteoporosis by hormone treatment of the menopause.
Can Med Assoc J. 1968 Aug 10;99(6):248-51 PMID: 5666826

Article Info

Journal

British medical journal

Abbr.

Br Med J

ISSN

0007-1447

DOI

10.1136/bmj.2.6090.789

Published

1977-09-24

Pages

789-92

Language

English

Region

England

NLM ID

0372673

PMCID

PMC1631969

Subset

External Links

PubMed source DOI: 10.1136/bmj.2.6090.789 PMC Full Text

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Prospective trial of oestrogen and calcium in postmenopausal women.

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