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PMID: 9126737 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Phenotype of mice lacking functional Deleted in colorectal cancer (Dcc) gene.

Nature ·Vol. 386 ·No. 6627 ·1997-04-24 ·Pages 796-804

Fazeli A, Dickinson SL, Hermiston ML, Tighe RV, Steen RG, Small CG, Stoeckli ET, Keino-Masu K, Masu M, Rayburn H, Simons J, Bronson RT, Gordon JI, Tessier-Lavigne M, Weinberg RA

Abstract

The DCC (Deleted in colorectal cancer) gene was first identified as a candidate for a tumour-suppressor gene on human chromosome 18q. More recently, in vitro studies in rodents have provided evidence that DCC might function as a receptor for the axonal chemoattractant netrin-1. Inactivation of the murine Dcc gene caused defects in axonal projections that are similar to those observed in netrin-1-deficient mice but did not affect growth, differentiation, morphogenesis or tumorigenesis in mouse intestine. These observations fail to support a tumour-suppressor function for Dcc, but are consistent with the hypothesis that DCC is a component of a receptor for netrin-1.

MeSH Terms

Animals Axons/pathology Brain/abnormalities,embryology Brain Neoplasms/genetics Cell Adhesion Molecules/genetics,physiology Cell Division Chimera Chromosome Mapping Colorectal Neoplasms/genetics DCC Receptor Gene Targeting Genes, DCC Humans Intestinal Mucosa/pathology Intestinal Neoplasms/genetics Intestinal Polyps/genetics Mice Mice, Inbred C57BL Mutagenesis Nerve Growth Factors/physiology Netrin-1 Phenotype Receptors, Cell Surface/metabolism Spinal Cord/abnormalities,embryology Tumor Suppressor Proteins

Chemicals

Cell Adhesion Molecules DCC Receptor DCC protein, human Dcc protein, mouse NTN1 protein, human Nerve Growth Factors Ntn1 protein, mouse Receptors, Cell Surface Tumor Suppressor Proteins Netrin-1

Authors & Affiliations

15 authors, click to expand affiliations / ORCID

Fazeli A

Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Cambridge 02142, USA.

Dickinson S L

Hermiston M L

Tighe R V

Steen R G

Small C G

Stoeckli E T

Keino-Masu K

Masu M

Rayburn H

Simons J

Bronson R T

Gordon J I

Tessier-Lavigne M

Weinberg R A

Article Info

Journal

Nature

Abbr.

Nature

ISSN

0028-0836

DOI

10.1038/386796a0

Published

1997-04-24

Pages

796-804

Language

English

Region

England

NLM ID

0410462

Subset

External Links

PubMed source DOI: 10.1038/386796a0 View journal details

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Phenotype of mice lacking functional Deleted in colorectal cancer (Dcc) gene.

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