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PMID: 9127169 Published · ppublish English Clinical Trial Journal Article Randomized Controlled Trial

A randomized, controlled trial of octreotide in the management of patients with acute pancreatitis.

International journal of pancreatology : official journal of the International Association of Pancreatology ·Vol. 21 ·No. 1 ·1997-02-00 ·Pages 13-9

McKay C, Baxter J, Imrie C

Abstract

In this study, octreotide was not found to be of benefit in the treatment of acute pancreatitis. Somatostatin and its long-acting analog octreotide have both been proposed for the treatment of patients with acute pancreatitis, but neither agent has been adequately assessed in patients with severe attacks. Fifty-eight patients with moderate or severe acute pancreatitis who were admitted to hospitals within the west of Scotland over an 18-mo period were randomized to receive octreotide, 40 micrograms/h, by continuous i.v. infusion for 5 d, or placebo in addition to standard supportive therapy. There was no significant difference in the incidence of complications (54% octreotide group and 40% placebo group) or mortality (octreotide group 18%; placebo group 20%).

MeSH Terms
Acute Disease Adult Aged Aged, 80 and over Female Humans Male Middle Aged Octreotide/adverse effects,therapeutic use Pancreatitis/drug therapy,mortality
Chemicals
Octreotide
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
McKay C
Department of Surgery, Glasgow Royal Infirmary, UK.
Baxter J
Imrie C
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28 references, click to expand
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Article Info
Journal
International journal of pancreatology : official journal of the International Association of Pancreatology
Abbr.
Int J Pancreatol
ISSN
0169-4197
DOI
10.1007/BF02785915
Published
1997-02-00
Pages
13-9
Language
English
Region
United States
NLM ID
8703511
Subset
IM
External Links
PubMed source DOI: 10.1007/BF02785915
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