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PMID: 9144181 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

The dTTPase mechanism of T7 DNA helicase resembles the binding change mechanism of the F1-ATPase.

Hingorani MM, Washington MT, Moore KC, Patel SS

Abstract

Bacteriophage T7 DNA helicase is a ring-shaped hexamer that catalyzes duplex DNA unwinding using dTTP hydrolysis as an energy source. Of the six potential nucleotide binding sites on the hexamer, we have found that three are noncatalytic sites and three are catalytic sites. The noncatalytic sites bind nucleotides with a high affinity, but dTTPs bound to these sites do not dissociate or hydrolyze through many dTTPase turnovers at the catalytic sites. The catalytic sites show strong cooperativity which leads to sequential binding and hydrolysis of dTTP. The elucidated dTTPase mechanism of the catalytic sites of T7 helicase is remarkably similar to the binding change mechanism of the ATP synthase. Based on the similarity, a general mechanism for hexameric helicases is proposed. In this mechanism, an F1-ATPase-like rotational movement around the single-stranded DNA, which is bound through the central hole of the hexamer, is proposed to lead to unidirectional translocation along single-stranded DNA and duplex DNA unwinding.

MeSH Terms
Bacteriophage T7/enzymology Binding Sites DNA Helicases/chemistry,isolation & purification,metabolism Kinetics Macromolecular Substances Models, Structural Proton-Translocating ATPases/chemistry,metabolism Pyrophosphatases/chemistry,isolation & purification,metabolism Thymine Nucleotides/metabolism
Chemicals
Macromolecular Substances Thymine Nucleotides Pyrophosphatases thymidine-triphosphatase Proton-Translocating ATPases DNA Helicases thymidine 5'-triphosphate
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Hingorani M M
Department of Biochemistry, Ohio State University, 484 West 12th Avenue, Columbus, OH 43210, USA.
Washington M T
Moore K C
Patel S S
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
Published
1997-05-13
Pages
5012-7
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC24622
Subset
IM
Grants
NIGMS NIH HHS · R01 GM055310 · United States
NIGMS NIH HHS · GM55310 · United States
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