Linkage of guinea pig Bf and C4 TO THE GPLA.

Inbred and partially inbred strains of guinea pigs were typed for their polymorphic Bf and C4 patterns. In crosses and backcrosses of inbred strains of guinea pigs the inheritance of Bf, C4, and GPLA phenotypes was studied. The presented data indicate linkage of the structural Bf and C4 loci to the major histocompatibility complex (MHC) of the guinea pig, the GPLA system. Evidence for a GPLA-B-Ia crossover was obtained. Bf and C4 typing contributes to the characterization of the GPLA region in some inbred strains thus providing a simple method for determining the state of inbreeding on the one hand and providing the necessary third or fourth region within the GPLA for the detection of informative meiosis, on the other.