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PMID: 9159172 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Early divergence of magnocellular and parvocellular functional subsystems in the embryonic primate visual system.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 94 ·No. 11 ·1997-05-27 ·Pages 5900-5

Meissirel C, Wikler KC, Chalupa LM, Rakic P

Abstract

In both human and Old World primates visual information is conveyed by two parallel pathways: the magnocellular (M) and parvocellular (P) streams that project to separate layers of the lateral geniculate nucleus and are involved primarily in motion and color/form discrimination. The present study provides evidence that retinal ganglion cells in the macaque monkey embryo diverge into M and P subtypes soon after their last mitotic division and that optic axons project directly and selectively to either the M or P moieties of the developing lateral geniculate nucleus. Thus, initial M projections from the eyes overlap only in prospective layers 1 and 2, whereas initial P projections overlap within prospective layers 3-6. We suggest that the divergence of the M and P pathways requires developmental mechanisms different from those underlying competition-driven segregation of initially intermixed eye-specific domains in the primate visual system.

MeSH Terms
Animals Cesarean Section Color Perception Embryonic and Fetal Development Female Form Perception Geniculate Bodies/embryology,physiology Gestational Age Humans Macaca/embryology Models, Neurological Motion Perception Neurons/physiology Pregnancy Retina/embryology,physiology Retinal Ganglion Cells/physiology Visual Pathways/embryology,physiology
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Meissirel C
Section of Neurobiology, Physiology, and Behavior, Department of Psychology, and the Center for Neuroscience, University of California, Davis, CA 95616-0657, USA.
Wikler K C
Chalupa L M
Rakic P
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.94.11.5900
Published
1997-05-27
Pages
5900-5
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC20878
Subset
IM
Grants
NEI NIH HHS · R01 EY002593 · United States
NEI NIH HHS · EY02593 · United States
NEI NIH HHS · EY03391 · United States
NEI NIH HHS · EY09917 · United States
External Links
PubMed source DOI: 10.1073/pnas.94.11.5900 PMC Full Text View journal details
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