DNA injection and genetic recombination of alkylated bacteriophage T7 in the presence of nalidixic acid.

Journal of virology ·Vol. 24 ·No. 2 ·1977-11-00 ·Pages 716-9

Karska-Wysocki B, Mamet-Bratley MD, Przewlocki G

Abstract

Marker rescue experiments with alkylated T7 bacteriophage carried out in the presence and in the absence of nalidixic acid suggest that the gradient in rescue is due to two alkylation-induced causes: a DNA injection defect and an interference with DNA synthesis.

MeSH Terms

Coliphages/drug effects,genetics,metabolism DNA, Viral/biosynthesis,genetics Genes, Viral Nalidixic Acid/pharmacology Recombination, Genetic/drug effects

Chemicals

DNA, Viral Nalidixic Acid

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Karska-Wysocki B

Mamet-Bratley M D

Przewlocki G

References (15)

15 references, click to expand

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Lethal and genetic effects of radiophosphorus decay in bacteriophages SP82G and T7.
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Effect of nalidixic acid on the growth of deoxyribonucleic acid bacteriophages.
J Virol. 1972 Jan;9(1):17-21 PMID: 4621668
Order of injection of T7 bacteriophage DNA.
J Virol. 1973 Jun;11(6):1024-6 PMID: 4576515
T4 and the rolling circle model of replication.
Annu Rev Genet. 1973;7:325-41 PMID: 4593307
Initiation and reinitiation of DNA synthesis during replication of bacteriophage T7.
Proc Natl Acad Sci U S A. 1972 Apr;69(4):998-1002 PMID: 4554539
Action of ethyl and methyl methane sulfonates on DNA injection and genetic recombination in T7 bacteriophage.
J Virol. 1976 Aug;19(2):318-24 PMID: 183007
Inactivation of the T7 coliphage by monofunctional alkylating agents. Action of phage adsorption and injection of its DNA.
Biochim Biophys Acta. 1976 Jun 18;435(2):184-91 PMID: 181068
DNA repair and recombination.
Br Med Bull. 1973 Sep;29(3):226-35 PMID: 4807325
Replication of bacteriophage M13. 8. Differential effects of rifampicin and nalidixic acid on the synthesis of the two strands of M13 duplex DNA.
J Mol Biol. 1974 Feb 15;83(1):63-82 PMID: 4817800
The genetics and physiology of bacteriophage T7.
Virology. 1969 Nov;39(3):562-74 PMID: 4902069
Molecular and genetic recombination of bacteriophage T4.
Annu Rev Genet. 1975;9:213-44 PMID: 1108766
Absence of interparental recombination in multiplicity reconstitution from incomplete bacteriophage T4 genomes.
J Virol. 1976 Jun;18(3):873-84 PMID: 1271533
Effects of radiophosphorus decay in bacteriophage T4D. II. The mechanism of marker rescue.
Virology. 1975 Nov;68(1):14-26 PMID: 1189293
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Article Info

Journal

Journal of virology

Abbr.

J Virol

ISSN

0022-538X

DOI

10.1128/JVI.24.2.716-719.1977

Published

1977-11-00

Pages

716-9

Language

English

Region

United States

NLM ID

0113724

PMCID

PMC515987

Subset

External Links

PubMed source DOI: 10.1128/JVI.24.2.716-719.1977 PMC Full Text View journal details

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DNA injection and genetic recombination of alkylated bacteriophage T7 in the presence of nalidixic acid.

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