Functional rafts in cell membranes.

Nature ·Vol. 387 ·No. 6633 ·1997-06-05 ·Pages 569-72

Simons K, Ikonen E

Abstract

A new aspect of cell membrane structure is presented, based on the dynamic clustering of sphingolipids and cholesterol to form rafts that move within the fluid bilayer. It is proposed that these rafts function as platforms for the attachment of proteins when membranes are moved around inside the cell and during signal transduction.

MeSH Terms

Animals Biological Transport Cell Membrane/physiology,ultrastructure Cholesterol/physiology Detergents Golgi Apparatus/physiology Humans Membrane Lipids/physiology Membrane Proteins/physiology Signal Transduction Solubility Sphingolipids/physiology

Chemicals

Detergents Membrane Lipids Membrane Proteins Sphingolipids Cholesterol

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Simons K

Ikonen E

Article Info

Journal

Nature

Abbr.

Nature

ISSN

0028-0836

DOI

10.1038/42408

Published

1997-06-05

Pages

569-72

Language

English

Region

England

NLM ID

0410462

Subset

External Links

PubMed source DOI: 10.1038/42408 View journal details

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Functional rafts in cell membranes.

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