Home LiteratureArticle Details

PMID: 9205057 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Frequency of Smad gene mutations in human cancers.

Cancer research ·Vol. 57 ·No. 13 ·1997-07-01 ·Pages 2578-80

Riggins GJ, Kinzler KW, Vogelstein B, Thiagalingam S

Abstract

Much excitement has recently been generated by the discovery of the Smad genes, encoding proteins that transduce signals from the transforming growth factor beta family of cytokines. Here, we report the completion of cloning of the six known human Smads, providing novel sequences for Smad5 and Smad6. Previously, Smad4 and Smad2 were shown to be mutated in human cancers. However, analysis of the other four Smad genes revealed no mutations in a total of 167 tumors, including those from colon, breast, lung, and pancreas. These results suggest that the various Smad genes have different functions and demonstrate that mutations in these four genes do not, in general, account for the widespread resistance to transforming growth factor beta that is found in human tumors.

MeSH Terms

Amino Acid Sequence Brain Neoplasms/genetics,metabolism Breast Neoplasms/genetics,metabolism Colorectal Neoplasms/genetics,metabolism DNA-Binding Proteins/genetics,metabolism Esophageal Neoplasms/genetics,metabolism Female Genes, Tumor Suppressor/genetics,physiology Head and Neck Neoplasms/genetics,metabolism Humans Lung Neoplasms/genetics,metabolism Male Molecular Sequence Data Mutation Neoplasms/genetics,metabolism Ovarian Neoplasms/genetics,metabolism Pancreatic Neoplasms/genetics,metabolism Phosphoproteins/genetics,metabolism Prostatic Neoplasms/genetics,metabolism Smad Proteins Smad2 Protein Smad3 Protein Smad4 Protein Smad5 Protein Smad6 Protein Stomach Neoplasms/genetics,metabolism Trans-Activators/genetics,metabolism Tumor Cells, Cultured

Chemicals

DNA-Binding Proteins Phosphoproteins SMAD2 protein, human SMAD3 protein, human SMAD4 protein, human SMAD5 protein, human SMAD6 protein, human Smad Proteins Smad2 Protein Smad3 Protein Smad4 Protein Smad5 Protein Smad6 Protein Trans-Activators

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Riggins G J

The Johns Hopkins Oncology Center, Baltimore, Maryland 21231, USA.

Kinzler K W

Vogelstein B

Thiagalingam S

Article Info

Journal

Cancer research

Abbr.

Cancer Res

ISSN

0008-5472

Published

1997-07-01

Pages

2578-80

Language

English

Region

United States

NLM ID

2984705R

Subset

Grants

NCI NIH HHS · CA43460 · United States

NCI NIH HHS · CA57345 · United States

External Links

PubMed source View journal details

Analysis Services

Frequency of Smad gene mutations in human cancers.

Contact

WeChat Official Account