Double indemnity: p53, BRCA and cancer. p53 mutation partially rescues developmental arrest in Brca1 and Brca2 null mice, suggesting a role for familial breast cancer genes in DNA damage repair.

Animals BRCA1 Protein/genetics,physiology BRCA2 Protein Breast Neoplasms/genetics Cyclin-Dependent Kinase Inhibitor p21 Cyclins/genetics DNA Repair DNA-Binding Proteins/genetics Female Humans Mice Mutation Neoplasm Proteins/genetics,physiology Rad51 Recombinase Signal Transduction Transcription Factors/genetics,physiology Tumor Suppressor Protein p53/genetics,physiology

BRCA1 Protein BRCA2 Protein CDKN1A protein, human Cdkn1a protein, mouse Cyclin-Dependent Kinase Inhibitor p21 Cyclins DNA-Binding Proteins Neoplasm Proteins Transcription Factors Tumor Suppressor Protein p53 RAD51 protein, human Rad51 Recombinase Rad51 protein, mouse