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PMID: 921246 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Plasmid-mediated resistance to gentamicin in Staphylococcus aureus.

Antimicrobial agents and chemotherapy ·Vol. 12 ·No. 4 ·1977-10-00 ·Pages 513-7

Wood DO, Carter MJ, Best GK

Abstract

Two strains isolated from a recent outbreak of infections by gentamicin-resistant Staphylococcus aureus were examined to determine whether genetic control of this resistance is plasmid or chromosomally mediated. Curing techniques indicated a plasmid location in both strains. Physical isolation and characterization of the plasmid deoxyribonucleic acid from one strain revealed that the determinant for gentamicin resistance resides on a 50S plasmid.

MeSH Terms

DNA, Bacterial/analysis Drug Resistance, Microbial Gentamicins/pharmacology Plasmids Rifampin/pharmacology Staphylococcus aureus/drug effects Temperature

Chemicals

DNA, Bacterial Gentamicins Rifampin

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Wood D O

Carter M J

Best G K

References (15)

15 references, click to expand

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A gentamycin resistance plasmid in Staphylococcus aureus.
Ann Microbiol (Paris). 1975 Jul-Aug;126B(1):91-4 PMID: 129020
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Article Info

Journal

Antimicrobial agents and chemotherapy

Abbr.

Antimicrob Agents Chemother

ISSN

0066-4804

DOI

10.1128/AAC.12.4.513

Published

1977-10-00

Pages

513-7

Language

English

Region

United States

NLM ID

0315061

PMCID

PMC429956

Subset

External Links

PubMed source DOI: 10.1128/AAC.12.4.513 PMC Full Text View journal details

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