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PMID: 9221784 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Cortistatin is expressed in a distinct subset of cortical interneurons.

The Journal of neuroscience : the official journal of the Society for Neuroscience ·Vol. 17 ·No. 15 ·1997-08-01 ·Pages 5868-80

de Lecea L, del Rio JA, Criado JR, Alcántara S, Morales M, Danielson PE, Henriksen SJ, Soriano E, Sutcliffe JG

Abstract

Cortistatin is a presumptive neuropeptide that shares 11 of its 14 amino acids with somatostatin. In contrast to somatostatin, administration of cortistatin into the rat brain ventricles specifically enhances slow wave sleep, apparently by antagonizing the effects of acetylcholine on cortical excitability. Here we show that preprocortistatin mRNA is expressed in a subset of GABAergic cells in the cortex and hippocampus that partially overlap with those containing somatostatin. A significant percentage of cortistatin-positive neurons is also positive for parvalbumin. In contrast, no colocalization was found between cortistatin and calretinin, cholecystokinin, or vasoactive intestinal peptide. During development there is a transient increase in cortistatin-expressing cells in the second postnatal week in all cortical areas and in the dentate gyrus. A transient expression of preprocortistatin mRNA in the hilar region at P16 is paralleled by electrophysiological changes in dentate granule cells. Together, these observations suggest mechanisms by which cortistatin may regulate cortical activity.

MeSH Terms
Animals Cerebral Cortex/metabolism In Situ Hybridization Interneurons/metabolism Neuropeptides/metabolism RNA, Messenger/metabolism Rats Rats, Sprague-Dawley
Chemicals
Neuropeptides RNA, Messenger cortistatin
Authors & Affiliations
9 authors, click to expand affiliations / ORCID
de Lecea L
Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA.
del Rio J A
Criado J R
Alcántara S
Morales M
Danielson P E
Henriksen S J
Soriano E
Sutcliffe J G
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Article Info
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
Abbr.
J Neurosci
ISSN
0270-6474
Published
1997-08-01
Pages
5868-80
Language
English
Region
United States
NLM ID
8102140
PMCID
PMC6573200
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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