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PMID: 9238038 Published · ppublish English Journal Article

Epithelial antibiotic induced in states of disease.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 94 ·No. 16 ·1997-08-05 ·Pages 8686-90

Stolzenberg ED, Anderson GM, Ackermann MR, Whitlock RH, Zasloff M

Abstract

Epithelial defensins provide an active defense against the external microbial environment. We investigated the distribution and expression of this class of antimicrobial peptides in normal cattle and in animals in varying states of disease. beta-defensin mRNA was found to be widely expressed in numerous exposed epithelia but was found at higher levels in tissues that are constantly exposed to and colonized by microorganisms. We observed induction in ileal mucosa during chronic infection with Mycobacterium paratuberculosis and in bronchial epithelium after acute infection with Pasteurella haemolytica. It has been proposed that expression of antimicrobial peptides is an integral component of the inflammatory response. The results reported here support this hypothesis and suggest that epithelial defensins provide a rapidly mobilized local defense against infectious organisms.

MeSH Terms
Animals Blood Proteins/biosynthesis Bronchi/metabolism,microbiology,physiopathology Cattle Defensins Epithelium/metabolism,microbiology,physiopathology In Situ Hybridization Intestinal Mucosa/metabolism,microbiology,physiopathology Mannheimia haemolytica Mycobacterium avium subsp. paratuberculosis Paratuberculosis/metabolism,physiopathology Pasteurella Infections/metabolism,physiopathology
Chemicals
Blood Proteins Defensins
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Stolzenberg E D
Magainin Research Institute, Magainin Pharmaceuticals, Inc., 5110 Campus Drive, Plymouth Meeting, PA 19462, USA.
Anderson G M
Ackermann M R
Whitlock R H
Zasloff M
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.94.16.8686
Published
1997-08-05
Pages
8686-90
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC23078
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.94.16.8686 PMC Full Text View journal details
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