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PMID: 9255069 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Phosphoinositide 3-kinases: a conserved family of signal transducers.

Trends in biochemical sciences ·Vol. 22 ·No. 7 ·1997-07-00 ·Pages 267-72

Vanhaesebroeck B, Leevers SJ, Panayotou G, Waterfield MD

Abstract

Phosphoinositide 3-kinases (PI3Ks) generate lipids that are implicated in receptor-stimulated signalling and in the regulation of membrane traffic. Several distinct classes of PI3Ks have now been identified that have been conserved throughout eukaryotic evolution. Potential signalling pathways downstream of PI3Ks have been elucidated and PI3K function is now being characterised in several model organisms.

MeSH Terms
Animals Caenorhabditis elegans/enzymology Dictyostelium/enzymology Drosophila melanogaster/enzymology Membrane Lipids/metabolism Molecular Sequence Data Phosphatidylinositol 3-Kinases Phosphotransferases (Alcohol Group Acceptor)/chemistry,classification,metabolism Signal Transduction Substrate Specificity
Chemicals
Membrane Lipids Phosphatidylinositol 3-Kinases Phosphotransferases (Alcohol Group Acceptor)
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Vanhaesebroeck B
Ludwig Institute for Cancer Research, London, UK.
Leevers S J
Panayotou G
Waterfield M D
Article Info
Journal
Trends in biochemical sciences
Abbr.
Trends Biochem Sci
ISSN
0968-0004
DOI
10.1016/s0968-0004(97)01061-x
Published
1997-07-00
Pages
267-72
Language
English
Region
England
NLM ID
7610674
Subset
IM
Databases
GENBANK
M59835, M93252, S67334, U03279, U23476, U23477, U23478, U23480, U52192, U52193, U55772, U56101, U57843, U86453, U86587, X53531, X85368, X92892, X99912, Y08991, Y09070, Y10055, Y10742, Y10743, Y11312, Y13367, Y13892, Z29090, Z46973, Z69660
External Links
PubMed source DOI: 10.1016/s0968-0004(97)01061-x View journal details
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