The genetic polymorphism of the fourth component of human complement: methodological aspects and a presentation of linkage and association data relevant to its localization in the HLA region.

The Journal of experimental medicine ·Vol. 146 ·No. 5 ·1977-11-01 ·Pages 1380-9

Teisberg P, Olaisen B, Jonassen R, Gedde-Dahl T, Thorsby E

Abstract

The C4 polymorphism in man has been studied by immunofixation electrophoresis, crossed immunoelectrophoresis, and functional detection after agarose gel electrophoresis. It has so far not been possible to reveal this polymorphism by isoelectric focusing and functional detection of C4 bands. Three common alleles and one less frequently occuring allele have been identified. In a small population sample studied by all the different techniques and verified by family segregation, the following gene frequencies have been found: C4F: 0.46, C4S: 0.32, C4F1: 0.20, and C4M: 0.02. By linkage and association studies in a family material it has been shown that a structural C4 locus is situated in the HLA region of chromosome 6 very close to the HLA-B and Bf loci.

MeSH Terms

Adult Alleles Child Complement C4/genetics Female Gene Frequency Genetic Linkage HLA Antigens Humans Immunoelectrophoresis, Two-Dimensional Male Pedigree Polymorphism, Genetic

Chemicals

Complement C4 HLA Antigens

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Teisberg P

Olaisen B

Jonassen R

Gedde-Dahl T

Thorsby E

References (21)

21 references, click to expand

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Article Info

Journal

The Journal of experimental medicine

Abbr.

J Exp Med

ISSN

0022-1007

DOI

10.1084/jem.146.5.1380

Published

1977-11-01

Pages

1380-9

Language

English

Region

United States

NLM ID

2985109R

PMCID

PMC2180975

Subset

External Links

PubMed source DOI: 10.1084/jem.146.5.1380 PMC Full Text View journal details

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The genetic polymorphism of the fourth component of human complement: methodological aspects and a presentation of linkage and association data relevant to its localization in the HLA region.

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