Transcriptional control: calling in histone deacetylase.

Current biology : CB ·Vol. 7 ·No. 8 ·1997-08-01 ·Pages R505-7

Kiermaier A, Eilers M

Abstract

Mad proteins are transcriptional repressors that antagonize transcriptional activation and transformation by Myc oncoprotein; recent findings suggest that they repress transcription by recruiting histone deacetylases to target sites on DNA.

MeSH Terms

Animals Basic Helix-Loop-Helix Leucine Zipper Transcription Factors Basic-Leucine Zipper Transcription Factors DNA-Binding Proteins/metabolism Gene Expression Regulation Histone Deacetylases/metabolism Humans Models, Biological Proto-Oncogene Proteins c-myc/metabolism Repressor Proteins/metabolism Transcription Factors Transcription, Genetic

Chemicals

Basic Helix-Loop-Helix Leucine Zipper Transcription Factors Basic-Leucine Zipper Transcription Factors DNA-Binding Proteins MAX protein, human MXD1 protein, human Myc associated factor X Proto-Oncogene Proteins c-myc Repressor Proteins Transcription Factors Histone Deacetylases

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Kiermaier A

Zentrum für Molekulare Biologie, Heidelberg, Germany.

Eilers M

Article Info

Journal

Current biology : CB

Abbr.

Curr Biol

ISSN

0960-9822

DOI

10.1016/s0960-9822(06)00249-1

Published

1997-08-01

Pages

R505-7

Language

English

Region

England

NLM ID

9107782

Subset

External Links

PubMed source DOI: 10.1016/s0960-9822(06)00249-1 View journal details

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