1,25-dihydroxyvitamin-D-receptor in breast cancer cells.

Lancet (London, England) ·Vol. 2 ·No. 8156-8157 ·1979-00-00 ·Pages 1335-6

Eisman JA, Martin TJ, MacIntyre I, Moseley JM

Abstract

A specific receptor for 1,25-dihydroxyvitamin D has been demonstrated in a cultured human breast cancer cell line. This is the first such demonstration in any cancer cell. It may explain the high incidence of metastatic bone destruction and hypercalcaemia in this common malignancy, and the limited success of other steroid-receptor assays in predicting the response of breast cancer to therapy.

MeSH Terms

Binding, Competitive Bone Neoplasms/etiology,secondary Breast/ultrastructure Breast Neoplasms/metabolism,pathology Calcium/metabolism Cell Line Cells, Cultured Cytosol/metabolism Dihydroxycholecalciferols/metabolism Female Humans Hydroxycholecalciferols/metabolism Hypercalcemia/etiology Receptors, Steroid/isolation & purification,metabolism

Chemicals

Dihydroxycholecalciferols Hydroxycholecalciferols Receptors, Steroid Calcium

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Eisman J A

Martin T J

MacIntyre I

Moseley J M

Article Info

Journal

Lancet (London, England)

Abbr.

Lancet

ISSN

0140-6736

DOI

10.1016/s0140-6736(79)92816-2

Published

1979-00-00

Pages

1335-6

Language

English

Region

England

NLM ID

2985213R

Subset

External Links

PubMed source DOI: 10.1016/s0140-6736(79)92816-2 View journal details

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