Fas- or ceramide-induced apoptosis is mediated by a Rac1-regulated activation of Jun N-terminal kinase/p38 kinases and GADD153.

Antigens, Surface/metabolism Apoptosis CCAAT-Enhancer-Binding Proteins Calcium-Calmodulin-Dependent Protein Kinases/metabolism Ceramides/pharmacology DNA Damage DNA-Binding Proteins/metabolism Fas Ligand Protein GTP-Binding Proteins/metabolism Humans JNK Mitogen-Activated Protein Kinases Jurkat Cells Ligands Membrane Glycoproteins/metabolism Mitogen-Activated Protein Kinases Nuclear Proteins/metabolism Phosphorylation Transcription Factor CHOP Transcription Factors/metabolism Transfection fas Receptor/pharmacology p38 Mitogen-Activated Protein Kinases rac GTP-Binding Proteins

Antigens, Surface CCAAT-Enhancer-Binding Proteins Ceramides DDIT3 protein, human DNA-Binding Proteins FASLG protein, human Fas Ligand Protein Ligands Membrane Glycoproteins Nuclear Proteins Transcription Factors fas Receptor Transcription Factor CHOP Calcium-Calmodulin-Dependent Protein Kinases JNK Mitogen-Activated Protein Kinases Mitogen-Activated Protein Kinases p38 Mitogen-Activated Protein Kinases GTP-Binding Proteins rac GTP-Binding Proteins