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PMID: 9294894 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S. Review

Loss of oxyR in Mycobacterium tuberculosis.

Trends in microbiology ·Vol. 5 ·No. 9 ·1997-09-00 ·Pages 367-72

Deretic V, Song J, Pagán-Ramos E

Abstract

The loss of the putative regulator oxyR and the associated dysfunction of oxidative stress response in Mycobacterium tuberculosis may have coincided with, or directly participated in, the evolution of this microorganism into the potent contemporary human pathogen. These phenomena may have implications for host-pathogen interactions in tuberculosis and for M. tuberculosis sensitivity to the front-line antituberculosis agent isoniazid.

MeSH Terms

Antitubercular Agents/therapeutic use Base Sequence DNA-Binding Proteins Drug Resistance, Microbial/genetics Gene Expression/physiology Host-Parasite Interactions/genetics Humans Isoniazid/therapeutic use Mycobacterium tuberculosis/genetics,physiology Oxidative Stress/genetics,physiology Repressor Proteins/genetics,physiology Sequence Deletion Transcription Factors/genetics,physiology Tuberculosis/drug therapy

Chemicals

Antitubercular Agents DNA-Binding Proteins Repressor Proteins Transcription Factors Isoniazid

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Deretic V

Dept of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor 48109-0620, USA. [email protected]

Song J

Pagán-Ramos E

Article Info

Journal

Trends in microbiology

Abbr.

Trends Microbiol

ISSN

0966-842X

DOI

10.1016/S0966-842X(97)01112-8

[email protected]

Published

1997-09-00

Pages

367-72

Language

English

Region

England

NLM ID

9310916

Subset

Grants

NIAID NIH HHS · AI25217 · United States

External Links

PubMed source DOI: 10.1016/S0966-842X(97)01112-8 View journal details

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Loss of oxyR in Mycobacterium tuberculosis.

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