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PMID: 9309704 Published · ppublish English Journal Article Review

Reactive oxygen species, mitochondria, apoptosis and aging.

Molecular and cellular biochemistry ·Vol. 174 ·No. 1-2 ·1997-09-00 ·Pages 305-19

Papa S, Skulachev VP

Abstract

In this paper, we shall review various antioxygen defense systems of the cell paying particular attention to those that prevent superoxide formation rather than scavenge already formed superoxide and its products. The role of uncoupled, decoupled and non-coupled respiration, mitochondrial pore, mitochondrion-linked apoptosis will be considered. Mitochondrial theory of aging will be regarded in context of reactive oxygen species-induced damage of mitochondrial DNA.

MeSH Terms
Aging/physiology Animals Apoptosis/physiology Humans Mitochondria/physiology Reactive Oxygen Species
Chemicals
Reactive Oxygen Species
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Papa S
Institute of Medical Biochemistry and Chemistry, University of Bari, Italy.
Skulachev V P
References (134)
134 references, click to expand
  1. The relationship between electron flux and the redox poise of the quinone pool in plant mitochondria. Interplay between quinol-oxidizing and quinone-reducing pathways.
    Eur J Biochem. 1994 Dec 15;226(3):1071-8 PMID: 7813462
  2. H+/e- stoichiometry of mitochondrial cytochrome complexes reconstituted in liposomes. Rate-dependent changes of the stoichiometry in the cytochrome c oxidase vesicles.
    FEBS Lett. 1991 Aug 19;288(1-2):179-82 PMID: 1652471
  3. Sequence and organization of the human mitochondrial genome.
    Nature. 1981 Apr 9;290(5806):457-65 PMID: 7219534
  4. Rapid accumulation of deleted mitochondrial deoxyribonucleic acid in postmenopausal ovaries.
    Biol Reprod. 1993 Oct;49(4):730-6 PMID: 8218635
  5. Conformational changes in oxidized phospholipids and their preferential hydrolysis by phospholipase A2: a monolayer study.
    Biochemistry. 1993 May 11;32(18):4962-7 PMID: 8490032
  6. Molecular and functional properties of mitochondrial benzodiazepine receptors.
    Biochim Biophys Acta. 1995 Dec 20;1241(3):453-70 PMID: 8547305
  7. Ultrastructural localization of bcl-2 protein.
    J Histochem Cytochem. 1992 Dec;40(12):1819-25 PMID: 1453000
  8. Modulation of the mitochondrial cyclosporin A-sensitive permeability transition pore by the proton electrochemical gradient. Evidence that the pore can be opened by membrane depolarization.
    J Biol Chem. 1992 May 5;267(13):8834-9 PMID: 1374381
  9. Generation of superoxide anion by the NADH dehydrogenase of bovine heart mitochondria.
    Biochem J. 1980 Nov 1;191(2):421-7 PMID: 6263247
  10. Functional and molecular changes in FoF1 ATP-synthase of cardiac muscle during aging.
    Cardioscience. 1993 Jun;4(2):93-8 PMID: 8347797
  11. Molecular aspects of isolated and reconstituted carrier proteins from animal mitochondria.
    Biochim Biophys Acta. 1989 Apr 17;974(1):1-23 PMID: 2647142
  12. Aging: a theory based on free radical and radiation chemistry.
    J Gerontol. 1956 Jul;11(3):298-300 PMID: 13332224
  13. Oxygen stress induces an apoptotic cell death associated with fragmentation of mitochondrial genome.
    Biochem Biophys Res Commun. 1995 Apr 17;209(2):723-9 PMID: 7733944
  14. Cellular organization for steroidogenesis.
    Int Rev Cytol. 1984;86:53-95 PMID: 6368449
  15. pH dependence of proton translocation by Escherichia coli.
    J Biol Chem. 1992 Jul 25;267(21):14559-62 PMID: 1321808
  16. Direct thyroid hormone activation of mitochondria: the role of adenine nucleotide translocase.
    Endocrinology. 1986 Jul;119(1):292-5 PMID: 3013590
  17. Aconitase, a two-faced protein: enzyme and iron regulatory factor.
    FASEB J. 1993 Dec;7(15):1442-9 PMID: 8262329
  18. Mechanistic and phenomenological features of proton pumps in the respiratory chain of mitochondria.
    J Bioenerg Biomembr. 1994 Dec;26(6):609-18 PMID: 7721722
  19. Molecular slipping in redox and ATPase H+ pumps.
    Biochim Biophys Acta. 1983 May 27;723(2):317-21 PMID: 6221758
  20. The role of intracellular oxidants in apoptosis.
    Biochim Biophys Acta. 1995 May 24;1271(1):59-62 PMID: 7599226
  21. The influence of respiration and ATP hydrolysis on the proton-electrochemical gradient across the inner membrane of rat-liver mitochondria as determined by ion distribution.
    Eur J Biochem. 1974 Dec 16;50(1):305-15 PMID: 4452361
  22. Unique action of a modified weakly acidic uncoupler without an acidic group, methylated SF 6847, as an inhibitor of oxidative phosphorylation with no uncoupling activity: possible identity of uncoupler binding protein.
    Biochim Biophys Acta. 1988 Mar 30;933(1):193-9 PMID: 2894856
  23. Amino acid identities in the three redox center-carrying polypeptides of cytochrome bc1/b6f complexes.
    J Bioenerg Biomembr. 1988 Apr;20(2):211-28 PMID: 2836381
  24. Cell-free apoptosis in Xenopus egg extracts: inhibition by Bcl-2 and requirement for an organelle fraction enriched in mitochondria.
    Cell. 1994 Oct 21;79(2):353-64 PMID: 7954801
  25. Some biochemical and physiochemical properties of the potent uncoupler SF 6847 (3,5-di-tert-butyl-4-hydroxybenzylidenemalononitrile).
    Biochim Biophys Acta. 1975 Jun 17;387(3):519-32 PMID: 237542
  26. Modelling the effects of age-related mtDNA mutation accumulation; complex I deficiency, superoxide and cell death.
    Biochim Biophys Acta. 1995 May 24;1271(1):171-6 PMID: 7599205
  27. Simultaneous overexpression of copper- and zinc-containing superoxide dismutase and catalase retards age-related oxidative damage and increases metabolic potential in Drosophila melanogaster.
    J Biol Chem. 1995 Jun 30;270(26):15671-4 PMID: 7797567
  28. Mitochondrial calcium transport: physiological and pathological relevance.
    Am J Physiol. 1994 Aug;267(2 Pt 1):C313-39 PMID: 8074170
  29. Nuclear but not mitochondrial genome involvement in human age-related mitochondrial dysfunction. Functional integrity of mitochondrial DNA from aged subjects.
    J Biol Chem. 1994 Mar 4;269(9):6878-83 PMID: 8120050
  30. Mitochondrial control of nuclear apoptosis.
    J Exp Med. 1996 Apr 1;183(4):1533-44 PMID: 8666911
  31. Mitochondrial oxidative phosphorylation changes in the life span. Molecular aspects and physiopathological implications.
    Biochim Biophys Acta. 1996 Sep 12;1276(2):87-105 PMID: 8816944
  32. Enzymic mechanisms of superoxide production.
    Biochim Biophys Acta. 1991 May 6;1057(3):281-98 PMID: 1851438
  33. Extension of life-span by overexpression of superoxide dismutase and catalase in Drosophila melanogaster.
    Science. 1994 Feb 25;263(5150):1128-30 PMID: 8108730
  34. The relative proton stoichiometries of the mitochondrial proton pumps are independent of the proton motive force.
    J Biol Chem. 1989 Sep 5;264(25):14704-9 PMID: 2549030
  35. A new oxygen-regulated operon in Escherichia coli comprises the genes for a putative third cytochrome oxidase and for pH 2.5 acid phosphatase (appA)
    Mol Gen Genet. 1991 Oct;229(3):341-52 PMID: 1658595
  36. Role of uncoupled and non-coupled oxidations in maintenance of safely low levels of oxygen and its one-electron reductants.
    Q Rev Biophys. 1996 May;29(2):169-202 PMID: 8870073
  37. Growth and physiology of Azotobacter chroococcum in continuous culture.
    J Gen Microbiol. 1969 Jun;56(3):307-19 PMID: 5797517
  38. Genetics of mitochondrial biogenesis.
    Annu Rev Biochem. 1986;55:249-85 PMID: 2427014
  39. Decline with age of the respiratory chain activity in human skeletal muscle.
    Biochim Biophys Acta. 1994 Apr 12;1226(1):73-82 PMID: 8155742
  40. Production of reactive oxygen by mitochondria from normoxic and hypoxic rat heart tissue.
    Free Radic Biol Med. 1992 Oct;13(4):289-97 PMID: 1383097
  41. Oxygen reactions with bacterial oxidases and globins: binding, reduction and regulation.
    Antonie Van Leeuwenhoek. 1994;65(4):289-310 PMID: 7832588
  42. Effects of 3,3',5-triiodo-L-thyronine (L-T3) and T3 analogues on mitochondrial function.
    Biochem Mol Biol Int. 1995 Apr;35(4):913-21 PMID: 7627140
  43. Absence of electron transport (Rho 0 state) restores growth of a manganese-superoxide dismutase-deficient Saccharomyces cerevisiae in hyperoxia. Evidence for electron transport as a major source of superoxide generation in vivo.
    J Biol Chem. 1993 Dec 15;268(35):26699-703 PMID: 8253804
  44. Bcl-2 functions in an antioxidant pathway to prevent apoptosis.
    Cell. 1993 Oct 22;75(2):241-51 PMID: 7503812
  45. Superoxide radical and iron modulate aconitase activity in mammalian cells.
    J Biol Chem. 1995 Jun 2;270(22):13399-405 PMID: 7768942
  46. Evidence for increased degeneration of mitochondria in old rats. A brief note.
    Mech Ageing Dev. 1978 Sep;8(3):197-201 PMID: 211355
  47. Redox-linked proton translocation in cytochrome oxidase: the importance of gating electron flow. The effects of slip in a model transducer.
    Biophys J. 1986 Oct;50(4):713-33 PMID: 3022836
  48. Altered peripheral benzodiazepine receptor binding in cardiac and liver tissues from thyroidectomized rats.
    Life Sci. 1994;55(24):1911-8 PMID: 7990651
  49. Mitochondrial regulation of superoxide by Ca2+: an alternate mechanism for the cardiotoxicity of doxorubicin.
    Toxicol Appl Pharmacol. 1991 Jan;107(1):117-28 PMID: 1702908
  50. Respiratory properties of cytochrome-c-deficient mutants of Azotobacter vinelandii.
    Eur J Biochem. 1980 Sep;110(2):349-54 PMID: 6254768
  51. Introduction of disease-related mitochondrial DNA deletions into HeLa cells lacking mitochondrial DNA results in mitochondrial dysfunction.
    Proc Natl Acad Sci U S A. 1991 Dec 1;88(23):10614-8 PMID: 1720544
  52. Evidence for superoxide radical-dependent coronary vasospasm after angioplasty in intact dogs.
    Circulation. 1991 May;83(5):1705-15 PMID: 1850666
  53. Human aging is associated with stochastic somatic mutations of mitochondrial DNA.
    Mutat Res. 1995 Oct;338(1-6):161-72 PMID: 7565871
  54. The interaction of highly active uncouplers with mitochondria.
    Biochim Biophys Acta. 1981 Dec 30;639(3-4):225-42 PMID: 7039674
  55. Mechanism of loss of thermodynamic control in mitochondria due to hyperthyroidism and temperature.
    J Biol Chem. 1992 Aug 5;267(22):15348-55 PMID: 1639781
  56. Ageing is associated in females with a decline in the content and activity on the b-c1 complex in skeletal muscle mitochondria.
    Biochim Biophys Acta. 1996 Jan 17;1315(1):66-72 PMID: 8611650
  57. Oxidative damage and mitochondrial decay in aging.
    Proc Natl Acad Sci U S A. 1994 Nov 8;91(23):10771-8 PMID: 7971961
  58. Cardiolipins and biomembrane function.
    Biochim Biophys Acta. 1992 Mar 26;1113(1):71-133 PMID: 1550861
  59. The mitochondrial permeability transition.
    Biochim Biophys Acta. 1995 Jul 17;1241(2):139-76 PMID: 7640294
  60. Dose-dependent induction of apoptosis in human tumour cell lines by widely diverging stimuli.
    Cell Prolif. 1991 Mar;24(2):203-14 PMID: 2009322
  61. [Generation of superoxide radicals by the mitochondrial respiratory chain of isolated cardiomyocytes].
    Biokhimiia. 1994 Jun;59(6):813-8 PMID: 8075245
  62. The voltage sensor of the mitochondrial permeability transition pore is tuned by the oxidation-reduction state of vicinal thiols. Increase of the gating potential by oxidants and its reversal by reducing agents.
    J Biol Chem. 1994 Jun 17;269(24):16638-42 PMID: 7515881
  63. Comparison of the effect of a mitochondrial uncoupler, 2,4-dinitrophenol and adrenaline on oxygen radical production in the isolated perfused rat liver.
    Acta Physiol Scand. 1992 Jun;145(2):159-68 PMID: 1322018
  64. bcl-XL is the major bcl-x mRNA form expressed during murine development and its product localizes to mitochondria.
    Development. 1994 Oct;120(10):3033-42 PMID: 7607090
  65. Oxygen activation and the conservation of energy in cell respiration.
    Nature. 1992 Mar 26;356(6367):301-9 PMID: 1312679
  66. The quantitative contributions of mitochondrial proton leak and ATP turnover reactions to the changed respiration rates of hepatocytes from rats of different thyroid status.
    J Biol Chem. 1993 Jul 15;268(20):14850-60 PMID: 8392060
  67. [Decrease in the intracellular concentration of O2 as a special function of the cellular respiratory system].
    Biokhimiia. 1994 Dec;59(12):1910-2 PMID: 7873690
  68. Investigation of the subcellular distribution of the bcl-2 oncoprotein: residence in the nuclear envelope, endoplasmic reticulum, and outer mitochondrial membranes.
    Cancer Res. 1993 Oct 1;53(19):4701-14 PMID: 8402648
  69. Respiratory-chain characteristics of mutants of Azotobacter vinelandii negative to tetramethyl-p-phenylenediamine oxidase.
    Eur J Biochem. 1979 Oct;100(1):19-27 PMID: 488089
  70. Bcl-2 blocks apoptosis in cells lacking mitochondrial DNA.
    Nature. 1993 Jan 28;361(6410):365-9 PMID: 8381212
  71. Investigation of the essential boundary layer phospholipids of cytochrome c oxidase using Triton X-100 delipidation.
    Biochemistry. 1980 Aug 5;19(16):3656-61 PMID: 6250574
  72. [Tiron as a spin-trap for superoxide radicals produced by the respiratory chain of submitochondrial particles].
    Biokhimiia. 1980 Jan;45(1):75-82 PMID: 6260236
  73. Modulation of membrane phospholipid fatty acid composition by age and food restriction.
    Gerontology. 1993;39(1):7-18 PMID: 8440492
  74. Persistent oxidative stress in cancer.
    FEBS Lett. 1995 Jan 16;358(1):1-3 PMID: 7821417
  75. Mitochondrial respiratory chain inhibitors induce apoptosis.
    FEBS Lett. 1994 Feb 14;339(1-2):40-4 PMID: 8313978
  76. Recent progress on regulation of the mitochondrial permeability transition pore; a cyclosporin-sensitive pore in the inner mitochondrial membrane.
    J Bioenerg Biomembr. 1994 Oct;26(5):509-17 PMID: 7896766
  77. Age-related changes of mitochondrial F0F1 ATP synthase.
    Ann N Y Acad Sci. 1992 Nov 30;671:395-402 PMID: 1288336
  78. Superoxide dismutase activity of cytochrome oxidase.
    Biochem Biophys Res Commun. 1978 Apr 28;81(4):1336-43 PMID: 27184
  79. Isolation of the eleven protein subunits of the bc1 complex from beef heart.
    Methods Enzymol. 1986;126:224-37 PMID: 2856130
  80. Superoxide generation by the respiratory chain of tumor mitochondria.
    Biochim Biophys Acta. 1987 Oct 29;894(1):1-10 PMID: 2822106
  81. The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen.
    Biochem J. 1973 Jul;134(3):707-16 PMID: 4749271
  82. Age-dependent changes in the mitochondrial F0F1 ATP synthase.
    Arch Gerontol Geriatr. 1992 May-Jun;14(3):299-308 PMID: 15374393
  83. Direct thyroid hormone activation of mitochondria: identification of adenine nucleotide translocase (AdNT) as the hormone receptor.
    Trans Assoc Am Physicians. 1987;100:284-93 PMID: 2842916
  84. Detection of a specific mitochondrial DNA deletion in tissues of older humans.
    Nucleic Acids Res. 1990 Dec 11;18(23):6927-33 PMID: 2263455
  85. Cytochrome o (bo) is a proton pump in Paracoccus denitrificans and Escherichia coli.
    FEBS Lett. 1989 Jun 5;249(2):163-7 PMID: 2544445
  86. Thyroid hormone action: identification of the mitochondrial thyroid hormone receptor as adenine nucleotide translocase.
    Thyroid. 1991;1(2):167-71 PMID: 1822364
  87. The regulation of intracellular transport of cholesterol in bovine adrenal cells: purification of a novel protein.
    Endocrinology. 1988 Oct;123(4):2075-82 PMID: 3416827
  88. The effect of superoxide generation on the ability of mitochondria to take up and retain Ca2+.
    FEBS Lett. 1982 Sep 20;146(2):267-72 PMID: 6291991
  89. Control of apoptosis by the cellular ATP level.
    FEBS Lett. 1996 Jan 8;378(2):107-10 PMID: 8549813
  90. The effect of hyperoxia on superoxide production by lung submitochondrial particles.
    Arch Biochem Biophys. 1982 Sep;217(2):401-10 PMID: 6291460
  91. Cloning and mutagenesis of genes encoding the cytochrome bd terminal oxidase complex in Azotobacter vinelandii: mutants deficient in the cytochrome d complex are unable to fix nitrogen in air.
    J Bacteriol. 1990 Oct;172(10):6010-9 PMID: 2170336
  92. Hydroperoxides can modulate the redox state of pyridine nucleotides and the calcium balance in rat liver mitochondria.
    Proc Natl Acad Sci U S A. 1979 Sep;76(9):4340-4 PMID: 41241
  93. The development of mitochondrial medicine.
    Proc Natl Acad Sci U S A. 1994 Sep 13;91(19):8731-8 PMID: 8090715
  94. Diseases of the mitochondrial DNA.
    Annu Rev Biochem. 1992;61:1175-212 PMID: 1497308
  95. Effect of oxygen on growth of Azotobacter chroococcum in batch and continuous cultures.
    J Gen Microbiol. 1968 Dec;54(3):463-73 PMID: 5709283
  96. Rapid stimulation of hepatic oxygen consumption by 3,5-di-iodo-L-thyronine.
    Biochem J. 1989 Aug 1;261(3):945-50 PMID: 2803254
  97. Inhibitors of permeability transition interfere with the disruption of the mitochondrial transmembrane potential during apoptosis.
    FEBS Lett. 1996 Apr 8;384(1):53-7 PMID: 8797802
  98. Permeability of inner mitochondrial membrane and oxidative stress.
    Biochim Biophys Acta. 1988 Aug 18;943(2):245-55 PMID: 3401479
  99. 6-ketocholestanol abolishes the effect of the most potent uncouplers of oxidative phosphorylation in mitochondria.
    FEBS Lett. 1994 Dec 5;355(3):305-8 PMID: 7988694
  100. The mechanism of the increase in mitochondrial proton permeability induced by thyroid hormones.
    Eur J Biochem. 1992 Jun 15;206(3):775-81 PMID: 1318835
  101. Human skeletal muscle mitochondria in aging: lack of detectable morphological and enzymic defects.
    Biochem Mol Biol Int. 1995 Nov;37(4):607-16 PMID: 8589633
  102. Slip and leak in mitochondrial oxidative phosphorylation.
    Biochim Biophys Acta. 1989 Nov 23;977(2):123-41 PMID: 2553111
  103. Thyroid hormone action on mitochondrial energy transfer.
    Biochim Biophys Acta. 1993 Aug 16;1144(1):1-16 PMID: 8347656
  104. Protective roles of cytokines against radiation: induction of mitochondrial MnSOD.
    Biochim Biophys Acta. 1995 May 24;1271(1):205-9 PMID: 7599209
  105. Protein oxidation and aging.
    Science. 1992 Aug 28;257(5074):1220-4 PMID: 1355616
  106. Alterations in mitochondrial structure and function are early events of dexamethasone-induced thymocyte apoptosis.
    J Cell Biol. 1995 Jul;130(1):157-67 PMID: 7790370
  107. A pattern of accumulation of a somatic deletion of mitochondrial DNA in aging human tissues.
    Proc Natl Acad Sci U S A. 1992 Aug 15;89(16):7370-4 PMID: 1502147
  108. Effect of thyroidectomy and adrenalectomy on changes in liver glutathione and malonaldehyde levels after acute ethanol injection.
    Free Radic Biol Med. 1993 Jun;14(6):655-60 PMID: 8325537
  109. Energy-dependent Complex I-associated ubisemiquinones in submitochondrial particles.
    FEBS Lett. 1995 Aug 14;370(1-2):83-7 PMID: 7649309
  110. Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death.
    Nature. 1990 Nov 22;348(6299):334-6 PMID: 2250705
  111. MELAS mutation in mtDNA binding site for transcription termination factor causes defects in protein synthesis and in respiration but no change in levels of upstream and downstream mature transcripts.
    Proc Natl Acad Sci U S A. 1992 May 15;89(10):4221-5 PMID: 1584755
  112. Coupling site I and the rotenone-sensitive ubisemiquinone in tightly coupled submitochondrial particles.
    FEBS Lett. 1990 May 7;264(1):17-20 PMID: 2159893
  113. Characteristics of energy-linked proton translocation in liposome reconstituted bovine cytochrome bc1 complex. Influence of the protonmotive force on the H+/e- stoichiometry.
    Eur J Biochem. 1992 Oct 1;209(1):475-81 PMID: 1327781
  114. Correlation between mitochondrial DNA 4977-bp deletion and respiratory chain enzyme activities in aging human skeletal muscles.
    Biochem Biophys Res Commun. 1994 Nov 30;205(1):772-9 PMID: 7999111
  115. The proton leak across the mitochondrial inner membrane.
    Biochim Biophys Acta. 1990 Jul 25;1018(2-3):128-33 PMID: 2393654
  116. Oxidative stress as a mediator of apoptosis.
    Immunol Today. 1994 Jan;15(1):7-10 PMID: 8136014
  117. Rat liver mitochondrial phospholipase A2 is an endotoxin-stimulated membrane-associated enzyme of Kupffer cells which is released during liver perfusion.
    Biochem J. 1993 Jul 1;293 ( Pt 1):143-50 PMID: 8328956
  118. The development of mitochondrial medicine.
    Biochim Biophys Acta. 1995 May 24;1271(1):1-6 PMID: 7599195
  119. [Inhibition of H2O2 and O2-. generation in the respiratory chain, treated with 2,3-dimercaptopropanol].
    Biokhimiia. 1982 Sep;47(9):1577-9 PMID: 6291643
  120. The cytochrome chain of mitochondria exhibits variable H+/e- stoichiometry.
    FEBS Lett. 1991 Aug 19;288(1-2):183-6 PMID: 1652472
  121. Thyroid hormone effect on rat heart mitochondrial proteins and affinity labeling with N-bromoacetyl-3,3',5-triiodo-L-thyronine. Lack of direct effect on the adenine nucleotide translocase.
    FEBS Lett. 1989 Sep 25;255(2):385-90 PMID: 2551739
  122. Effect of 3,3'-di-iodothyronine and 3,5-di-iodothyronine on rat liver mitochondria.
    J Endocrinol. 1993 Jan;136(1):59-64 PMID: 8381457
  123. The effect of age on mitochondrial ultrastructure and enzymes.
    Adv Exp Med Biol. 1975;53:171-83 PMID: 164102
  124. A 3D model of the peripheral benzodiazepine receptor and its implication in intra mitochondrial cholesterol transport.
    J Mol Graph. 1993 Dec;11(4):236-44, 235 PMID: 8136326
  125. Different in situ hybridization patterns of mitochondrial DNA in cytochrome c oxidase-deficient extraocular muscle fibres in the elderly.
    Virchows Arch A Pathol Anat Histopathol. 1993;422(1):7-15 PMID: 7679851
  126. Apoptosis-associated derangement of mitochondrial function in cells lacking mitochondrial DNA.
    Cancer Res. 1996 May 1;56(9):2033-8 PMID: 8616847
  127. Properties of the two terminal oxidases of Escherichia coli.
    Biochemistry. 1991 Apr 23;30(16):3936-42 PMID: 1850294
  128. Effects of the general anaesthetic Propofol on the Ca2(+)-induced permeabilization of rat liver mitochondria.
    FEBS Lett. 1991 Feb 11;279(1):45-8 PMID: 1704857
  129. Bioenergetics in aging.
    Biochim Biophys Acta. 1983 Apr 15;726(1):41-80 PMID: 6338921
  130. Activation of molecular oxygen by flavins and flavoproteins.
    J Biol Chem. 1994 Sep 9;269(36):22459-62 PMID: 8077188
  131. Flux ratios and pump stoichiometries at sites II and III in liver mitochondria. Effect of slips and leaks.
    J Biol Chem. 1991 Jan 15;266(2):1034-42 PMID: 1845985
  132. Peroxidative damage to cardiac mitochondria. II. Immunological analysis of modified adenine nucleotide translocase.
    Arch Biochem Biophys. 1994 Nov 15;315(1):1-7 PMID: 7979384
  133. Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species.
    Science. 1993 Nov 19;262(5137):1274-7 PMID: 8235659
  134. Effects of thyroid hormones on oxidative phosphorylation.
    Biochem Soc Trans. 1993 Aug;21 ( Pt 3)(3):785-92 PMID: 8224511
Article Info
Journal
Molecular and cellular biochemistry
Abbr.
Mol Cell Biochem
ISSN
0300-8177
Published
1997-09-00
Pages
305-19
Language
English
Region
Netherlands
NLM ID
0364456
Subset
IM
External Links
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