Increased microvascular permeability to plasma proteins in short- and long-term juvenile diabetics.

Diabetes ·Vol. 25 ·No. 2 SUPPL ·1976-00-00 ·Pages 884-9

Parving HH

Abstract

The present findings of increased microvascular protein passage are compatible with the hypothesis that the organic, histologically demonstrated diabetic microangiopathy is a long-term effect of periods of increased extravasation of plasma proteins, with subsequent protein deposition in the microvascular wall, i.e., the concept of plasmatic vasculosis. Arterial hypertension, frequently present in diabetes, enhances the development of arteriolar hyalinosis. Effective treatment of diabetes and hypertension arrests development of the microvascular lesions.

MeSH Terms

Adolescent Adult Blood Blood Pressure Blood Proteins/metabolism Blood Volume Capillaries/physiopathology Diabetes Complications Diabetes Mellitus, Type 1/physiopathology Diabetic Angiopathies/etiology,physiopathology,prevention & control Glucose/metabolism Humans Hydrogen-Ion Concentration Hypertension/complications Immunoglobulin G/metabolism Male Permeability Serum Albumin/metabolism Time Factors beta 2-Microglobulin/metabolism

Chemicals

Blood Proteins Immunoglobulin G Serum Albumin beta 2-Microglobulin Glucose

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Parving H H

Article Info

Journal

Diabetes

Abbr.

Diabetes

ISSN

0012-1797

Published

1976-00-00

Pages

884-9

Language

English

Region

United States

NLM ID

0372763

Subset

External Links

PubMed source View journal details

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Increased microvascular permeability to plasma proteins in short- and long-term juvenile diabetics.

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