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PMID: 9335341 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

A role for the roof plate and its resident TGFbeta-related proteins in neuronal patterning in the dorsal spinal cord.

Cell ·Vol. 91 ·No. 1 ·1997-10-03 ·Pages 127-38

Liem KF, Tremml G, Jessell TM

Abstract

Distinct neuronal cell types are generated at characteristic times and positions in the dorsal horn of the spinal cord. We provide evidence that the identity and pattern of generation of dorsal neurons depend initially on BMP-mediated signals that derive from the epidermal ectoderm and induce dorsal midline cells of the roof plate. Roof plate cells provide a secondary source of TGFbeta-related signals that are required for the generation of distinct classes of dorsal interneurons. These inductive interactions involve both qualitative and quantitative differences in signaling by TGFbeta-related factors and temporal changes in the response of neural progenitor cells.

MeSH Terms
Activins Animals Biomarkers Body Patterning/genetics,physiology Bone Morphogenetic Proteins/genetics,pharmacology,physiology Carrier Proteins Cell Differentiation Chick Embryo Ectoderm/physiology Embryonic Induction/physiology Epidermis/embryology Follistatin Gene Expression Regulation, Developmental Glycoproteins/pharmacology Homeodomain Proteins/analysis Inhibins/genetics,pharmacology Interneurons/cytology Molecular Sequence Data Neural Crest/embryology Notochord/transplantation Proteins/pharmacology Rats Signal Transduction/physiology Spinal Cord/cytology,embryology Transforming Growth Factor beta/physiology
Chemicals
Biomarkers Bone Morphogenetic Proteins Carrier Proteins Follistatin Glycoproteins Homeodomain Proteins Proteins Transforming Growth Factor beta Activins noggin protein Inhibins
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Liem K F
Department of Biochemistry and Molecular Biophysics, Center for Neurobiology and Behavior, Columbia University, New York, New York 10032, USA.
Tremml G
Jessell T M
Article Info
Journal
Cell
Abbr.
Cell
ISSN
0092-8674
DOI
10.1016/s0092-8674(01)80015-5
Published
1997-10-03
Pages
127-38
Language
English
Region
United States
NLM ID
0413066
Subset
IM
Grants
NIGMS NIH HHS · 5T32GM07367 · United States
Databases
GENBANK
L35566
External Links
PubMed source DOI: 10.1016/s0092-8674(01)80015-5 View journal details
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