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PMID: 9349813 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

The capsaicin receptor: a heat-activated ion channel in the pain pathway.

Nature ·Vol. 389 ·No. 6653 ·1997-10-23 ·Pages 816-24

Caterina MJ, Schumacher MA, Tominaga M, Rosen TA, Levine JD, Julius D

Abstract

Capsaicin, the main pungent ingredient in 'hot' chilli peppers, elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the central nervous system. We have used an expression cloning strategy based on calcium influx to isolate a functional cDNA encoding a capsaicin receptor from sensory neurons. This receptor is a non-selective cation channel that is structurally related to members of the TRP family of ion channels. The cloned capsaicin receptor is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo.

MeSH Terms

Afferent Pathways/metabolism Amino Acid Sequence Animals Calcium/metabolism Calcium Channels/chemistry Capsaicin/metabolism,pharmacology Capsicum Cell Death/drug effects Cell Line Cloning, Molecular Drosophila Proteins Electrophysiology Hot Temperature Humans Insect Proteins/chemistry Ion Channel Gating Ion Channels/genetics,metabolism Molecular Sequence Data Neurons, Afferent/metabolism Neurotoxins/metabolism,pharmacology Nociceptors/metabolism Plants, Medicinal Protons Receptors, Drug/chemistry,genetics,metabolism Sequence Homology, Amino Acid Transient Receptor Potential Channels Xenopus

Chemicals

Calcium Channels Drosophila Proteins Insect Proteins Ion Channels Neurotoxins Protons Receptors, Drug Transient Receptor Potential Channels trp protein, Drosophila Capsaicin Calcium

Authors & Affiliations

6 authors, click to expand affiliations / ORCID

Caterina M J

Department of Cellular and Molecular Pharmacology, University of California, San Francisco 94143-0450, USA.

Schumacher M A

Tominaga M

Rosen T A

Levine J D

Julius D

Article Info

Journal

Nature

Abbr.

Nature

ISSN

0028-0836

DOI

10.1038/39807

Published

1997-10-23

Pages

816-24

Language

English

Region

England

NLM ID

0410462

Subset

Databases

GENBANK

AF029310

Corrections

CommentIn

PMID: 9349801

External Links

PubMed source DOI: 10.1038/39807 View journal details

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The capsaicin receptor: a heat-activated ion channel in the pain pathway.

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