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PMID: 9350616 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Photodynamic triggering of calcium oscillation in the isolated rat pancreatic acini.

The Journal of physiology ·Vol. 504 ( Pt 1) ·1997-10-01 ·Pages 47-55

Cui ZJ, Kanno T

Abstract

1. Photodynamic agents, due to their photon-dependent selective activation, can selectively activate a number of physiological processes and may directly modulate signal transduction in a number of cells including pancreatic acinar cells. 2. Activation of the photodynamic agent sulphonated aluminium phthalocyanine (SALPC) triggered recurrent cytosolic calcium ([Ca2+]i) spiking in pancreatic acinar cells. 3. The photodynamically triggered calcium spiking could be blocked by phosphatidylinositol-specific phospholipase C (PI-PLC) inhibitor U73122, but not by phosphatidylcholine-specific phospholipase C inhibitor D609. 4. Removal of extracellular Ca2+ abolished spiking, as did 2-aminoethoxydiphenylborate (2-APB), an inhibitory modulator of IP3-mediated Ca2+ release from intracellular stores. 5. These data suggest that SALPC photodynamic action may permanently fix PI-PLC in an active conformation, and this produced recurrent [Ca2+]i spiking.

MeSH Terms
Animals Bridged-Ring Compounds/pharmacology Calcium/metabolism,radiation effects Enzyme Inhibitors/pharmacology Estrenes/pharmacology In Vitro Techniques Indoles/pharmacology Male Norbornanes Organometallic Compounds/pharmacology Pancreas/drug effects,metabolism,radiation effects Phosphodiesterase Inhibitors/pharmacology Photic Stimulation Pyrrolidinones/pharmacology Rats Rats, Sprague-Dawley Thiocarbamates Thiones/pharmacology Type C Phospholipases/antagonists & inhibitors
Chemicals
Bridged-Ring Compounds Enzyme Inhibitors Estrenes Indoles Norbornanes Organometallic Compounds Phosphodiesterase Inhibitors Pyrrolidinones Thiocarbamates Thiones 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione aluminum tetrasulfophthalocyanine tricyclodecane-9-yl-xanthogenate Type C Phospholipases Calcium
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Cui Z J
Beijing Agricultural University Faculty of Biological Sciences, People's Republic of China. [email protected]
Kanno T
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33 references, click to expand
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Article Info
Journal
The Journal of physiology
Abbr.
J Physiol
ISSN
0022-3751
DOI
10.1111/j.1469-7793.1997.047bf.x
Email
[email protected]
Published
1997-10-01
Pages
47-55
Language
English
Region
England
NLM ID
0266262
PMCID
PMC1159934
Subset
IM
External Links
PubMed source DOI: 10.1111/j.1469-7793.1997.047bf.x PMC Full Text View journal details
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