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PMID: 9353036 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Failure to block adhesion of Plasmodium falciparum-infected erythrocytes to ICAM-1 with soluble ICAM-1.

Infection and immunity ·Vol. 65 ·No. 11 ·1997-11-00 ·Pages 4580-5

Craig AG, Pinches R, Khan S, Roberts DJ, Turner GD, Newbold CI, Berendt AR

Abstract

The adhesion of Plasmodium falciparum-infected erythrocytes is thought to play a central role in the pathogenesis of severe malaria. ICAM-1 has been identified as one of the host receptors for parasitized erythrocytes and has been implicated as being involved in progression to cerebral malaria. Thus, intervention strategies based on the reversal of this interaction could potentially be used to reduce morbidity and mortality. We have investigated the inhibition of the interaction between ICAM-1 and infected erythrocytes by using recombinant soluble ICAM-1 as competitor and find that we are unable to reduce adhesion to ICAM-1 in vitro.

MeSH Terms
Animals COS Cells Cell Adhesion Erythrocytes/parasitology,physiology Intercellular Adhesion Molecule-1/physiology Plasmodium falciparum/physiology Recombinant Proteins/pharmacology
Chemicals
Recombinant Proteins Intercellular Adhesion Molecule-1
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Craig A G
Molecular Parasitology Group, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, United Kingdom. [email protected]
Pinches R
Khan S
Roberts D J
Turner G D
Newbold C I
Berendt A R
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.65.11.4580-4585.1997
Email
[email protected]
Published
1997-11-00
Pages
4580-5
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC175657
Subset
IM
Grants
Wellcome Trust · United Kingdom
External Links
PubMed source DOI: 10.1128/iai.65.11.4580-4585.1997 PMC Full Text View journal details
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