T-cell signaling: the importance of receptor clustering.

Current biology : CB ·Vol. 7 ·No. 10 ·1997-10-01 ·Pages R640-4

Germain RN

Abstract

T-cell receptors bound to peptide-MHC molecules undergo higher-order oligomerization in solution. This observation, the low-affinity-recognition properties of T-cell receptors, and other indications that such receptors undergo rapid, serial engagement by a single ligand suggest a dynamic clustering model of T-cell signaling.

MeSH Terms

Animals B-Lymphocytes/immunology,metabolism CD4 Antigens/metabolism Histocompatibility Antigens Class II/metabolism Humans Receptors, Antigen, T-Cell/metabolism Signal Transduction T-Lymphocytes/immunology,metabolism

Chemicals

CD4 Antigens Histocompatibility Antigens Class II Receptors, Antigen, T-Cell

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Germain R N

Lymphocyte Biology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892-1892, USA.

Article Info

Journal

Current biology : CB

Abbr.

Curr Biol

ISSN

0960-9822

DOI

10.1016/s0960-9822(06)00323-x

Published

1997-10-01

Pages

R640-4

Language

English

Region

England

NLM ID

9107782

Subset

External Links

PubMed source DOI: 10.1016/s0960-9822(06)00323-x View journal details

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