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PMID: 938120 Published · ppublish English Journal Article

Suppression of gastrin release and gastric secretion by gastric inhibitory polypeptide (GIP) and vasoactive intestinal polypeptide (VIP).

Annals of surgery ·Vol. 184 ·No. 1 ·1976-07-00 ·Pages 97-102

Villar HV, Fender HR, Rayford PL, Bloom SR, Ramus NI, Thompson JC

Abstract

Five dogs prepared with Heidenhain pouches received infusions of saline, GIP and VIP before and after a standard meat meal. Blood samples were obtained under basal conditions and at subsequent intervals for measurement of gastrin, insulin, GIP and VIP by radioimmunoassay. GIP and VIP infusions had no effect on basal levels of gastrin. GIP and VIP (in common with secretin and glucagon) were found to suppress food-stimulated release of gastrin and gastrin-stimulated acid secretion from the Heidenhain pouch. Insulin levels were significantly elevated during GIP and VIP infusions. Food released GIP (and perhaps VIP.

MeSH Terms
Animals Blood Glucose/analysis Depression, Chemical Dogs Gastric Juice/metabolism Gastric Mucosa/metabolism Gastrins/blood,metabolism Glucagon/pharmacology Insulin/blood Intestine, Small Peptides/pharmacology Pylorus/metabolism Secretin/pharmacology
Chemicals
Blood Glucose Gastrins Insulin Peptides Secretin Glucagon
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Villar H V
Fender H R
Rayford P L
Bloom S R
Ramus N I
Thompson J C
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19 references, click to expand
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Article Info
Journal
Annals of surgery
Abbr.
Ann Surg
ISSN
0003-4932
DOI
10.1097/00000658-197607000-00016
Published
1976-07-00
Pages
97-102
Language
English
Region
United States
NLM ID
0372354
PMCID
PMC1344314
Subset
IM
External Links
PubMed source DOI: 10.1097/00000658-197607000-00016 PMC Full Text View journal details
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