Isochromosome X in man: different DNA replication patterns in the long arms.

Human genetics ·Vol. 33 ·No. 1 ·1976-07-07 ·Pages 55-60

Baranovskaya LI, Egolina NA, Zakharov AF, Tsvetkova TG

Abstract

An X isochromosome for the long arm was studied in 3 patients with Turner's syndrome using the BrdUrd-Hoechst 33258-Giemsa method and C-staining. In all 3 patients studied, the long arms of the i(Xq) were asymmetrical with respect to chronology of DNA synthesis. The most striking asynchrony of DNA replication was observed in large early replicating segments adjacent to the centromeric region. Two C bands of similar appearance were observed localized symmetrically in both arms. The data are interpreted in accordance with two possible origins of an abnormal X which is known as i(Xq).

MeSH Terms

DNA Replication Female Heterochromatin/analysis Humans Sex Chromosomes/metabolism Time Factors Turner Syndrome/genetics

Chemicals

Heterochromatin

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Baranovskaya L I

Egolina N A

Zakharov A F

Tsvetkova T G

References (11)

11 references, click to expand

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Article Info

Journal

Human genetics

Abbr.

Hum Genet

ISSN

0340-6717

DOI

10.1007/BF00447286

Published

1976-07-07

Pages

55-60

Language

English

Region

Germany

NLM ID

7613873

Subset

External Links

PubMed source DOI: 10.1007/BF00447286 View journal details

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Isochromosome X in man: different DNA replication patterns in the long arms.

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