Abstract
An unknown environmental agent has been suspected to induce systemic lupus erythematosus (lupus) in man. Prompted by our recent immunochemical findings, we sought evidence for an association between Epstein-Barr virus infection and lupus. Because the vast majority of adults have been infected with Epstein-Barr virus, we chose to study children and young adults. Virtually all (116 of 117, or 99%) of these young patients had seroconverted against Epstein-Barr virus, as compared with only 70% (107 of 153) of their controls (odds ratio 49.9, 95% confidence interval 9.3-1025, P < 0. 00000000001). The difference in the rate of Epstein-Barr virus seroconversion could not be explained by serum IgG level or by cross-reacting anti-Sm/nRNP autoantibodies. No similar difference was found in the seroconversion rates against four other herpes viruses. An assay for Epstein-Barr viral DNA in peripheral blood lymphocytes established Epstein-Barr virus infection in the peripheral blood of all 32 of the lupus patients tested, while only 23 of the 32 matched controls were infected (odds ratio > 10, 95% confidence interval 2.53-infinity, P < 0.002). When considered with other evidence supporting a relationship between Epstein-Barr virus and lupus, these data are consistent with, but do not in themselves establish, Epstein-Barr virus infection as an etiologic factor in lupus.
MeSH Terms
Adolescent
Adult
Antibodies, Viral/blood,immunology
Antigens, Viral/immunology
Capsid Proteins
Child
Child, Preschool
DNA, Viral/analysis
Herpesviridae Infections/complications,epidemiology,immunology
Herpesvirus 4, Human/genetics,immunology,isolation & purification
Humans
Lupus Erythematosus, Systemic/blood,immunology,virology
Prevalence
Tumor Virus Infections/complications,epidemiology,immunology
Chemicals
Antibodies, Viral
Antigens, Viral
Capsid Proteins
DNA, Viral
Epstein-Barr viral capsid antigen
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
James J A
Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA.
Kaufman K M
Farris A D
Taylor-Albert E
Lehman T J
Harley J B
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