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PMID: 9420336 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

windbeutel, a gene required for dorsoventral patterning in Drosophila, encodes a protein that has homologies to vertebrate proteins of the endoplasmic reticulum.

Genes & development ·Vol. 12 ·No. 1 ·1998-01-01 ·Pages 120-31

Konsolaki M, Schüpbach T

Abstract

The formation of the dorsoventral axis of the Drosophila embryo depends on cell-cell interactions that take place in the female ovary and involve the activation of transmembrane receptors by secreted ligands. The gene windbeutel functions in the somatic follicle cells of the ovary and is required for the generation of a signal that will determine the ventral side of the embryo. This signal originates in the follicle cells during oogenesis, but its actions are only manifested after fertilization, when the egg has already been laid. We have performed a molecular analysis of windbeutel. We have found that windbeutel encodes a putative resident protein of the endoplasmic reticulum, and has homologs in rats and humans. The gene is expressed for a brief period of time in the follicle cells of the ovary, at around the time when the dorsoventral axis of the egg chamber is first established. We propose that Windbeutel is responsible for the folding and/or modification of a specific factor that is secreted from the follicle cells and participates in the activation of the ventralizing signal.

MeSH Terms
Amino Acid Sequence Animals Base Sequence Body Patterning/genetics,physiology Chromosome Mapping DNA, Complementary Drosophila/embryology,genetics Drosophila Proteins Endoplasmic Reticulum/metabolism Female Humans Insect Proteins/genetics,physiology Molecular Sequence Data Mutation Oogenesis Ovarian Follicle/cytology,metabolism Phenotype Protein Folding Rats Sequence Analysis, DNA Sequence Homology, Amino Acid
Chemicals
DNA, Complementary Drosophila Proteins Insect Proteins wbl protein, Drosophila
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Konsolaki M
Howard Hughes Medical Institute, Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA.
Schüpbach T
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Article Info
Journal
Genes & development
Abbr.
Genes Dev
ISSN
0890-9369
DOI
10.1101/gad.12.1.120
Published
1998-01-01
Pages
120-31
Language
English
Region
United States
NLM ID
8711660
PMCID
PMC316405
Subset
IM
Grants
NCI NIH HHS · P01 CA041086 · United States
NCI NIH HHS · P01 CA 41086 · United States
Databases
GENBANK
AF025408
External Links
PubMed source DOI: 10.1101/gad.12.1.120 PMC Full Text View journal details
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