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PMID: 9430736 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S. Review

HLA-G polymorphisms: neutral evolution or novel function?

Journal of reproductive immunology ·Vol. 36 ·No. 1-2 ·1997-11-30 ·Pages 1-21

Ober C, Aldrich CL

Abstract

HLA-G is a non-classical class Ib gene with many unusual features. Because of its unique expression pattern, which is primarily limited to fetal cells at the maternal fetal interface, this gene has gained the attention of many investigators. In this paper we review some of the novel features of HLA-G, with particular reference to polymorphic variants in the gene, and discuss the implications of these features for the potential function and evolutionary history of HLA-G.

MeSH Terms

Alleles Alternative Splicing Base Sequence Codon/genetics Evolution, Molecular Female Fetus/immunology Genes, MHC Class I HLA Antigens/chemistry,genetics,physiology HLA-A Antigens/genetics HLA-G Antigens Histocompatibility Antigens Class I/chemistry,genetics,physiology Humans Linkage Disequilibrium Models, Molecular Mutation Polymorphism, Genetic Pregnancy RNA, Messenger/genetics,metabolism

Chemicals

Codon HLA Antigens HLA-A Antigens HLA-G Antigens Histocompatibility Antigens Class I RNA, Messenger

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Ober C

Department of Obstetrics and Gynecology, University of Chicago, IL 60637, USA. [email protected]

Aldrich C L

Article Info

Journal

Journal of reproductive immunology

Abbr.

J Reprod Immunol

ISSN

0165-0378

DOI

10.1016/s0165-0378(97)00062-4

[email protected]

Published

1997-11-30

Pages

1-21

Language

English

Region

Ireland

NLM ID

8001906

Subset

Grants

NICHD NIH HHS · HD21244 · United States

NICHD NIH HHS · HD27686 · United States

External Links

PubMed source DOI: 10.1016/s0165-0378(97)00062-4 View journal details

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