The dilatatory action of adenosine on pial arteries of cats and its inhibition by theophylline.
The effect of adenosine upon pial resistance vessels was studied using local microapplication from the perivascular side and measurement of vascular diameter. Concentration-response curves revealed a concentration-dependent dilatatory effect of adenosine between 10(-7) and 10(-3) M. The degree of dilatation was independent of initial vessel size (47-260 mu). The dilatations due to adenosine could be reduced by theophylline in a reversible competitive antagonism. Concentration-response curves for theophylline yielded no vascular reaction at concentrations of up to 10(-5) M theophylline. From these data is is concluded that the pial arterial resting tone is not influenced under our experimental conditions by adenosine formed and released by brain tissue. The dilatations measured at high theophylline concentrations are apparently due to a mechanism different from the adenosine antagonism.
17 references, click to expand
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Relationship between adenosine concentration and oxygen supply in rat brain.Am J Physiol. 1975 Jun;228(6):1896-902 PMID: 168787
-
Sites of adenosine production in cardiac and skeletal muscle.Am J Physiol. 1973 Oct;225(4):938-53 PMID: 4743384
-
Dependency of pial arterial and arteriolar diameter on perivascular osmolarity in the cat. A microapplication study.Circ Res. 1973 Feb;32(2):162-9 PMID: 4685960
-
Inhibition of various cyclic AMP phosphodiesterases by pentifylline and theophylline.Arzneimittelforschung. 1974 Nov;24(11):1747-51 PMID: 4374953
-
Cerebral and renal vascular smooth muscle responses to adenosine.Am J Physiol. 1969 Dec;217(6):1660-4 PMID: 5353041
-
Micropuncture evaluation of the importance of perivascular pH for the arteriolar diameter on the brain surface.Pflugers Arch. 1970;316(2):152-63 PMID: 5461680
-
Blood gas tensions and acid-base balance in awake cats.J Appl Physiol. 1971 Mar;30(3):434-6 PMID: 5544129
-
Release of adenosine by the normal myocardium in dogs and its relationship to the regulation of coronary resistance.Circ Res. 1969 Oct;25(4):407-15 PMID: 5347222
-
[On the location of the flow resistance in the cerebral circulation].Pflugers Arch. 1969 Jun 24;310(1):75-85 PMID: 5816089
-
Perivascular potassium and pH as determinants of local pial arterial diameter in cats. A microapplication study.Circ Res. 1972 Aug;31(2):240-7 PMID: 5049739
-
Cyclic nucleotide phosphodiesterase inhibition and vascular smooth muscle relaxation.Eur J Pharmacol. 1972 Jul;19(1):134-6 PMID: 4340226
-
Drug effects on regional cerebral blood flow in focal cerebrovascular disease.J Neurol Sci. 1973 Aug;19(4):461-82 PMID: 4146812
-
Pressures in the pial arterial microcirculation of the cat during changes in systemic arterial blood pressure.Circ Res. 1972 Aug;31(2):229-39 PMID: 5049738
-
The effect of intracarotid aminophylline infusion on the cerebral circulation.Stroke. 1972 Sep-Oct;3(5):560-5 PMID: 4652730
-
Is decrease of cerebral blood flow after intravenous injections of theophylline due to direct vasoconstrictive action of the drug?Eur Neurol. 1971-1972;6(1):153-7 PMID: 5153418
-
[Decomposition of free nucleotides in the rat heart, skeletal muscle, brain and liver in oxygen deficiency].Pflugers Arch Gesamte Physiol Menschen Tiere. 1966;292(3):239-54 PMID: 5234192
-
Coronary responses to dilating substances and competitive inhibition by theophylline in the isolated perfused guinea pig heart.Pflugers Arch. 1975 Jul 28;358(3):213-24 PMID: 1239001
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