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PMID: 9448323 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Readily releasable pool size changes associated with long term depression.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 95 ·No. 3 ·1998-02-03 ·Pages 1283-8

Goda Y, Stevens CF

Abstract

We have estimated, for hippocampal neurons in culture, the size of the autaptic readily releasable pool before and after stimulation of the sort that produces culture long term depression (LTD). This stimulation protocol causes a decrease in the pool size that is proportional to the depression of synaptic currents. To determine if depression in this system is synapse specific rather than general, we have also monitored synaptic transmission between pairs of cultured hippocampal neurons that are autaptically and reciprocally interconnected. We find that the change in synaptic strength is restricted to the synapses on the target neuron that were active during LTD induction. When viewed from the perspective of the presynaptic neuron, however, synapse specificity is partial rather than complete: synapses active during induction that were not on the target neuron were partially depressed.

MeSH Terms
Animals Animals, Newborn Cells, Cultured Hippocampus/physiology Neuronal Plasticity/physiology Neurons/physiology Presynaptic Terminals/physiology Rats Synapses/physiology Synaptic Transmission/physiology
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Goda Y
Molecular Neurobiology Laboratory and Howard Hughes Medical Institute, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.
Stevens C F
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.95.3.1283
Published
1998-02-03
Pages
1283-8
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC18746
Subset
IM
Grants
NINDS NIH HHS · NS 12961 · United States
External Links
PubMed source DOI: 10.1073/pnas.95.3.1283 PMC Full Text View journal details
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