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PMID: 948754 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Acetylcholine hot spots: development on myotubes cultured from aneural limb buds.

Science (New York, N.Y.) ·Vol. 193 ·No. 4256 ·1976-09-03 ·Pages 915-7

Bekoff A, Betz WJ

Abstract

The hypothesis that neural induction plays a role in the development of acetylcholine hot spots (high-sensitivity regions) was tested by electrophysiological mapping of the distribution of acetylcholine sensitivity of myotubes derived from aneural hindlimb buds of chick embryos. Hot spots were found. Therefore, hot spot development is not dependent on prior contact with nerve processes.

MeSH Terms

Acetylcholine/pharmacology Animals Chick Embryo Embryonic Induction Muscles/embryology Neuromuscular Junction/embryology Receptors, Cholinergic

Chemicals

Receptors, Cholinergic Acetylcholine

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Bekoff A

Betz W J

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.948754

Published

1976-09-03

Pages

915-7

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.948754 View journal details

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Acetylcholine hot spots: development on myotubes cultured from aneural limb buds.

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