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PMID: 949346 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

A sparing effect of increased plasma fatty acids on muscle and liver glycogen content in the exercising rat.

The Biochemical journal ·Vol. 156 ·No. 3 ·1976-06-15 ·Pages 647-55

Rennie MJ, Winder WW, Holloszy JO

Abstract

Increasing plasma free fatty acids decreased the degree of glycogen depletion, and increased the citrate concentration, in slow-red (soleus) and fast-red (deep portion of vastus lateralis) muscle during exercise (approx. 50% depletion of glycogen, as against 75% in control animals). There was no effect in fast-white muscle (superficial portion of vastus lateralis). Glycogen concentration in the liver decreased by 83% in controls, but only by 23% in animals with increased free fatty acids during exercise. The decreased glycogen depletion may be partly explained by the findings that (a) plasma-insulin concentration was two- to three-fold higher in animals with increased plasma free fatty acids and (b) the exercise-induced increase in plasma glucagon was lessened by increased free fatty acids. Blood glucose was higher in the animals with increased free fatty acids after the exercise. The rats with increased plasma free fatty acids utilized approx. 50% as much carbohydrate as did the controls during the exercise.

MeSH Terms
Animals Blood Glucose/analysis Citrates/analysis Fatty Acids/blood,pharmacology Glucagon/blood Glycogen/metabolism Insulin/blood Lactates/analysis Liver Glycogen/metabolism Male Muscles/drug effects Physical Exertion Rats
Chemicals
Blood Glucose Citrates Fatty Acids Insulin Lactates Liver Glycogen Glycogen Glucagon
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Rennie M J
Winder W W
Holloszy J O
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47 references, click to expand
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Article Info
Journal
The Biochemical journal
Abbr.
Biochem J
ISSN
0264-6021
DOI
10.1042/bj1560647
Published
1976-06-15
Pages
647-55
Language
English
Region
England
NLM ID
2984726R
PMCID
PMC1163799
Subset
IM
External Links
PubMed source DOI: 10.1042/bj1560647 PMC Full Text View journal details
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