Home LiteratureArticle Details
PMID: 9527814 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

QacA multidrug efflux pump from Staphylococcus aureus: comparative analysis of resistance to diamidines, biguanidines, and guanylhydrazones.

Antimicrobial agents and chemotherapy ·Vol. 42 ·No. 2 ·1998-02-00 ·Pages 475-7

Mitchell BA, Brown MH, Skurray RA

Abstract

The staphylococcal multidrug efflux pump QacA mediates resistance to a broad spectrum of monovalent and divalent antimicrobial cations. Resistance toward various classes of these compounds identified features of the substrate that may be important for interaction with QacA. Analysis of combinations of two substrates suggested that the same mechanism is used for the extrusion of different classes of compounds.

MeSH Terms
Bacterial Proteins/metabolism Benzamidines/pharmacology Biguanides/pharmacology Carrier Proteins/metabolism Drug Resistance, Multiple/physiology Enzyme Inhibitors/pharmacology Membrane Transport Proteins Mitoguazone/analogs & derivatives,pharmacology Staphylococcus aureus/drug effects,metabolism
Chemicals
Bacterial Proteins Benzamidines Biguanides Carrier Proteins Enzyme Inhibitors Membrane Transport Proteins qacA protein, Staphylococcus aureus Mitoguazone
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Mitchell B A
School of Biological Sciences, University of Sydney, New South Wales, Australia.
Brown M H
Skurray R A
References (9)
9 references, click to expand
  1. In vitro packaging of lambda and cosmid DNA.
    Methods Enzymol. 1979;68:299-309 PMID: 161604
  2. Physical and biochemical characterization of the qacA gene encoding antiseptic and disinfectant resistance in Staphylococcus aureus.
    J Gen Microbiol. 1989 Jan;135(1):1-10 PMID: 2778425
  3. Efflux-mediated antiseptic resistance gene qacA from Staphylococcus aureus: common ancestry with tetracycline- and sugar-transport proteins.
    Mol Microbiol. 1990 Dec;4(12):2051-62 PMID: 2089219
  4. Substrate specificity and energetics of antiseptic and disinfectant resistance in Staphylococcus aureus.
    FEMS Microbiol Lett. 1992 Aug 15;74(2-3):259-65 PMID: 1526458
  5. Proton-dependent multidrug efflux systems.
    Microbiol Rev. 1996 Dec;60(4):575-608 PMID: 8987357
  6. In vitro activities of metronidazole and its hydroxy metabolite against Bacteroides spp.
    Antimicrob Agents Chemother. 1994 Sep;38(9):2106-10 PMID: 7811027
  7. Guanylhydrazones in therapy of Pneumocystis carinii pneumonia in immunosuppressed rats.
    Antimicrob Agents Chemother. 1994 Nov;38(11):2572-6 PMID: 7872750
  8. Multidrug resistance proteins QacA and QacB from Staphylococcus aureus: membrane topology and identification of residues involved in substrate specificity.
    Proc Natl Acad Sci U S A. 1996 Apr 16;93(8):3630-5 PMID: 8622987
  9. A major superfamily of transmembrane facilitators that catalyse uniport, symport and antiport.
    Trends Biochem Sci. 1993 Jan;18(1):13-20 PMID: 8438231
Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
DOI
10.1128/AAC.42.2.475
Published
1998-02-00
Pages
475-7
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC105442
Subset
IM
External Links
PubMed source DOI: 10.1128/AAC.42.2.475 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2