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PMID: 9554838 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Structure and function in the nucleus.

Science (New York, N.Y.) ·Vol. 280 ·No. 5363 ·1998-04-24 ·Pages 547-53

Lamond AI, Earnshaw WC

Abstract

Current evidence suggests that the nucleus has a distinct substructure, albeit one that is dynamic rather than a rigid framework. Viral infection, oncogene expression, and inherited human disorders can each cause profound and specific changes in nuclear organization. This review summarizes recent progress in understanding nuclear organization, highlighting in particular the dynamic aspects of nuclear structure.

MeSH Terms
Animals Cell Nucleolus/physiology,ultrastructure Cell Nucleus/chemistry,physiology,ultrastructure Chromatin/physiology Chromosomes/physiology Drosophila Proteins Euchromatin Gene Expression Regulation Heterochromatin/physiology Humans Insect Proteins/chemistry,physiology Interphase Neoplasm Proteins/chemistry,physiology Nuclear Proteins Polycomb Repressive Complex 1 Polycomb-Group Proteins Promyelocytic Leukemia Protein Repressor Proteins/chemistry,physiology Ribonucleoproteins, Small Nuclear/analysis,physiology Transcription Factors/chemistry,physiology Tumor Suppressor Proteins
Chemicals
Chromatin Drosophila Proteins Euchromatin Heterochromatin Insect Proteins Neoplasm Proteins Nuclear Proteins Pc protein, Drosophila Polycomb-Group Proteins Promyelocytic Leukemia Protein Repressor Proteins Ribonucleoproteins, Small Nuclear Transcription Factors Tumor Suppressor Proteins PML protein, human Polycomb Repressive Complex 1
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Lamond A I
Department of Biochemistry, University of Dundee, Dundee DD1 4HN, Scotland, UK. [email protected]
Earnshaw W C
Article Info
Journal
Science (New York, N.Y.)
Abbr.
Science
ISSN
0036-8075
DOI
10.1126/science.280.5363.547
Email
[email protected]
Published
1998-04-24
Pages
547-53
Language
English
Region
United States
NLM ID
0404511
Subset
IM
Grants
Wellcome Trust · 073915 · United Kingdom
External Links
PubMed source DOI: 10.1126/science.280.5363.547 View journal details
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