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PMID: 9582068 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S. Review

Allosteric effects of DNA on transcriptional regulators.

Nature ·Vol. 392 ·No. 6679 ·1998-04-30 ·Pages 885-8

Lefstin JA, Yamamoto KR

Abstract

Selective gene transcription is mediated in part by regulatory proteins that bind to DNA response elements. These regulatory proteins receive global information from signal-transduction events. But transcriptional regulators may also be modified in an allosteric manner by response elements themselves to generate the pattern of regulation that is appropriate to an individual gene.

MeSH Terms

Allosteric Regulation DNA/chemistry,metabolism DNA-Binding Proteins/chemistry,metabolism Dimerization Gene Expression Regulation Protein Conformation Receptors, Cytoplasmic and Nuclear/chemistry,metabolism Regulatory Sequences, Nucleic Acid Signal Transduction Transcription Factors/chemistry,metabolism Transcription, Genetic

Chemicals

DNA-Binding Proteins Receptors, Cytoplasmic and Nuclear Transcription Factors DNA

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Lefstin J A

Department of Cellular and Molecular Pharmacology, University of California, San Francisco 94143-0450, USA. [email protected]

Yamamoto K R

Article Info

Journal

Nature

Abbr.

Nature

ISSN

0028-0836

DOI

10.1038/31860

[email protected]

Published

1998-04-30

Pages

885-8

Language

English

Region

England

NLM ID

0410462

Subset

External Links

PubMed source DOI: 10.1038/31860 View journal details

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Allosteric effects of DNA on transcriptional regulators.

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