Emerging targets for the development of novel antifungal therapeutics.

Trends in microbiology ·Vol. 6 ·No. 3 ·1998-03-00 ·Pages 117-24

Groll AH, De Lucca AJ, Walsh TJ

Abstract

Invasive mycoses have become important causes of morbidity and mortality in immunocompromised patients. New approaches for antifungal therapy are required to meet the challenges imposed by these life-threatening infections. Such approaches are being developed through identification of novel biochemical and molecular targets of pathogenic fungi.

MeSH Terms

Antifungal Agents/chemistry,pharmacology Cell Membrane/chemistry,drug effects,metabolism Cell Wall/chemistry,drug effects DNA, Fungal/metabolism Fungal Proteins/biosynthesis Peptide Elongation Factors/biosynthesis Signal Transduction

Chemicals

Antifungal Agents DNA, Fungal Fungal Proteins Peptide Elongation Factors

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Groll A H

Immunocompromised Host Section, National Cancer Institute, NIH, Bethesda, MD, USA.

De Lucca A J

Walsh T J

Article Info

Journal

Trends in microbiology

Abbr.

Trends Microbiol

ISSN

0966-842X

DOI

10.1016/s0966-842x(97)01206-7

Published

1998-03-00

Pages

117-24

Language

English

Region

England

NLM ID

9310916

Subset

External Links

PubMed source DOI: 10.1016/s0966-842x(97)01206-7 View journal details

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Emerging targets for the development of novel antifungal therapeutics.

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