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PMID: 9600909 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Selective activation of JNK1 is necessary for the anti-apoptotic activity of hILP.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 95 ·No. 11 ·1998-05-26 ·Pages 6015-20

Sanna MG, Duckett CS, Richter BW, Thompson CB, Ulevitch RJ

Abstract

The balance between the inductive signals and endogenous anti-apoptotic mechanisms determines whether or not programmed cell death occurs. The widely expressed inhibitor of apoptosis gene family includes three closely related mammalian proteins: c-IAP1, c-IAP2, and hILP. The anti-apoptotic properties of these proteins have been linked to caspase inhibition. Here we show that one member of this group, hILP, inhibits interleukin-1beta-converting enzyme-induced apoptosis via a mechanism dependent on the selective activation of c-Jun N-terminal kinase 1. These data demonstrate that apoptosis can be inhibited by an endogenous cellular protein by a mechanism that requires the activation of a single member of the mitogen-activating protein kinase family.

MeSH Terms
Animals Apoptosis/drug effects,physiology COS Cells Calcium-Calmodulin-Dependent Protein Kinases/physiology Cysteine Endopeptidases/pharmacology Enzyme Activation Humans JNK Mitogen-Activated Protein Kinases Mitogen-Activated Protein Kinases Proteins/physiology Signal Transduction/physiology Transfection X-Linked Inhibitor of Apoptosis Protein
Chemicals
Proteins X-Linked Inhibitor of Apoptosis Protein XIAP protein, human Calcium-Calmodulin-Dependent Protein Kinases JNK Mitogen-Activated Protein Kinases Mitogen-Activated Protein Kinases Cysteine Endopeptidases
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Sanna M G
The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
Duckett C S
Richter B W
Thompson C B
Ulevitch R J
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.95.11.6015
Published
1998-05-26
Pages
6015-20
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC27577
Subset
IM
Grants
NIDDK NIH HHS · P01DK49799 · United States
NIAID NIH HHS · AI15136 · United States
NIGMS NIH HHS · P01 GM037696 · United States
NIGMS NIH HHS · GM37696 · United States
NIAID NIH HHS · R01 AI015136 · United States
External Links
PubMed source DOI: 10.1073/pnas.95.11.6015 PMC Full Text View journal details
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