B-cell receptor regulation of peripheral B cells.

Current opinion in immunology ·Vol. 10 ·No. 2 ·1998-04-00 ·Pages 220-5

MacLennan IC

Abstract

Recent studies indicate that immature B cells compete with recirculating B cells for survival signals. The signals, delivered through the B-cell receptor for antigen, induce immature cells to differentiate into recirculating cells and maintain the survival of recirculating cells. They do not induce proliferation or differentiation to antibody-producing cells.

MeSH Terms

Animals B-Lymphocytes/cytology,physiology Cell Differentiation/physiology Cell Movement/physiology Cell Survival/physiology Humans Mice Receptors, Antigen, B-Cell/physiology Signal Transduction/physiology

Chemicals

Receptors, Antigen, B-Cell

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

MacLennan I C

Department of Immunology, University of Birmingham Medical School, UK. [email protected]

Article Info

Journal

Current opinion in immunology

Abbr.

Curr Opin Immunol

ISSN

0952-7915

DOI

10.1016/s0952-7915(98)80252-5

[email protected]

Published

1998-04-00

Pages

220-5

Language

English

Region

England

NLM ID

8900118

Subset

External Links

PubMed source DOI: 10.1016/s0952-7915(98)80252-5 View journal details

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B-cell receptor regulation of peripheral B cells.

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