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PMID: 9637792 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S. Review

The Environmental Genome Project: functional analysis of polymorphisms.

Environmental health perspectives ·Vol. 106 ·No. 7 ·1998-07-00 ·Pages 365-8

Guengerich FP

Abstract

The ultimate goal of the Environmental Genome Project is the improvement of human health on the basis of information about the variations in certain genes. The first phase of the project will involve the selection of the human genes and characterization of the alleles occurring in the American population. However, intelligent use of this information will require analysis of the relevance of the allelic differences. Epidemiology alone will not solve the problem, and mechanistic studies will be required. Factors to be considered in the design of functional analyses are considered in this commentary.

MeSH Terms
Environmental Pollutants/toxicity Genetic Diseases, Inborn/chemically induced,epidemiology Genome Humans Mutagens/toxicity National Institutes of Health (U.S.) United States/epidemiology
Chemicals
Environmental Pollutants Mutagens
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Guengerich F P
Department of Biochemistry and Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, USA.
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Article Info
Journal
Environmental health perspectives
Abbr.
Environ Health Perspect
ISSN
0091-6765
DOI
10.1289/ehp.98106365
Published
1998-07-00
Pages
365-8
Language
English
Region
United States
NLM ID
0330411
PMCID
PMC1533131
Subset
IM
Grants
NIEHS NIH HHS · P30 ES00267 · United States
NCI NIH HHS · R35 CA44353 · United States
External Links
PubMed source DOI: 10.1289/ehp.98106365 PMC Full Text View journal details
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